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Completed

NCT Number: NCT02951494

Impact of Lower Body Weight Support Treadmill on Cardiopulmonary Exercise Capacity and Trainability

The AlterG®-anti-gravity treadmill provides lower body weight support which enables individuals to exercise without feeling their full body weight. How this body weight support influences cardiovascular, respiratory, vascular and metabolic parameters is currently unclear. Further, whether body weight support influences the trainability in response to moderate continuous exercise is unknown. This investigation has two main goals. First, we explore the direct influence of lower body weight support on cardiometabolic parameters during maximal exercise testing. Second, we aim to compare changes in cardiorespiratory fitness in response to a structured exercise protocol using moderate intensity with and without lower body weight support.

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Key information

Conditions

Healthy Volunteers

Age range

18 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cardiovascular examination center of the University Medicine Greifswald

Greifswald, 17489, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • maximal oxygen consumption below age-sex specific standard

Exclusion criteria

  • acute infection within the last four weeks
  • anemia (males: Hb < 8.1 mmol/L; females Hb < 7.4 mmol/L)
  • previous reports of myo-, endo, or pericarditis
  • previous stroke or acute myocardial infarction
  • heart failure (NYHA > 1)
  • aortic valve stenosis
  • congenital heart disease
  • cardiomyopathy
  • severe left ventricular hypertrophy
  • cardiac arrythmias
  • hypertension
  • diabetes
  • BMI > 35
  • cancer
  • pregnancy
  • aneurysm of aorta or cerebral arteries

Treatment and study plan

AlterG Anti-gravity treadmill

Other

Participants in this group will complete a 12 week aerobic exercise training protocol with 40% lower body weight support on an AlterG Anti-gravity treadmill

Primary outcomes

  1. Maximal oxygen consumption

    Time frame: 12 weeks

    VO2peak [ml/min]

Secondary outcomes

  1. Oxygen consumption at anaerobic threshold

    Time frame: 12 weeks

    VO2@AT

  2. Pulse wave velocity

    Time frame: 12 weeks

Sponsors and collaborators

Lead sponsor

University Medicine Greifswald

Other

Registry information

Official study title

Einfluss Der Körpergewichtsunterstützung Auf Einem AlterG®-Antigravitationslaufband Auf Die Kardiopulmonale Leistungsfähigkeit Und Trainierbarkeit

Important dates

Study start
2017
Primary completion
2021
Study completion
2021
First posted
Nov 1, 2016
Registry last updated
May 25, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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