Skip to main content
OpenTrials
Completed

NCT Number: NCT07676396

Impact of Intracanal Cryotherapy and Corticosteroids on Post Endodontic Pain

The aim of the study: is to evaluate efficiency of using either intracanal corticosteroids or intracanal cryotherapy as a final flush irrigation on post endodontic pain in lower molar teeth with symptomatic irreversible pulpitis. The materials and methods: In this study forty patients with symptomatic irreversible pulpitis in lower molar teeth with pain level of 4 or higher on the visual analogue scale (VAS) will be selected.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Symptomatic Irreversible Pulpitis (SIP) Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

October 6 university

Giza, Egypt

About this study

This study will involve 40 adult patients (18-60 years) for both genders equally .all of patients must provide written informed consent and commit to the full trial period. Eligible participants must present with a lower molar diagnosed with symptomatic irreversible pulpitis, characterized by moderate-to-severe preoperative pain (VAS score ≥ 4) that lingers after stimulus removal. Conversely, the study excludes vulnerable groups (e.g., pregnant or mentally ill), medically compromised individuals, and those who have taken analgesics or antibiotics. Specific dental exclusions include teeth with open apices, calcified canals, prior endodontic treatment, or periodontally affected tooth

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • both gender -
  • age range of (18-60 years ) -medical free patients with lower molars with symptomatic irreversible pulpitis and indicated for single visit root canal treatment with pain score 4 or more on VAS- Patients that commit for the entire period of the trial and agreed to sign the informed consent .

Exclusion criteria

  • vulnerable group -teeth with open apex or calcified canals-curved canals-
  • patients on analgesics or antibiotics
  • periodontaly affected tooth

Treatment and study plan

Dexamethasone

Drug

intra root canal final flush of 5ml of 4mg/ml dexamethasone before obturation

cold saline

Other

intra root canal final flush of 20ml of cold saline before obturation

cold sodium hypochlorite

Other

intra root canal final flush of 20ml of cold sodium hypochlorite before obturation

Primary outcomes

  1. postoperative pain

    Time frame: 1 year

    assessment of post operative pain after single visit root canal treatment using vasual analogue scale

Sponsors and collaborators

Lead sponsor

October 6 University

Other

Registry information

Official study title

Efficiency Of Intracanal Cryotherapy Versus Corticosteroids As Final Irrigation On Post Operative Pain Level In Patients With Symptomatic Irreversible Pulpitis Randomized Control Trial

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jun 30, 2026
Registry last updated
Jun 30, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.