Skip to main content
OpenTrials
Completed

NCT Number: NCT01209637

Impact of Intensive Exercise Training on Coronary Collateral Circulation in Patients With Stable CAD

Exercise training in patients with coronary artery disease is able to correct several risk factors. Furthermore endothelial function can be improved.

There are some hinds for improved collateral circulation after exercise training, nevertheless there is no study showing significant improvement/ increase in coronary collaterals. This might be due to technique of collateral measurement. Therefore we conduct a study were coronary blod flow before and after 4 weeks of exercise training were measured.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Stable Coronary Artery Disease

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Heart Center Leipzig- University Leipzig

Leipzig, 04289, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • stable CAD
  • min.1 coronary artery stenosis >50%
  • patient is symptomatic ( CCS 1-3)or has documented myocardial ischemia during stress test
  • angina threshold >75 Watt
  • informed consent

Exclusion criteria

  • Age <18 oder >75
  • akut coronary syndrome within 2 weeks
  • LV-EF < 40 %
  • significant valve diseases
  • reduced patient compliance
  • muscular disorder
  • bronchial asthma or COLD stadium III and IV

Treatment and study plan

Exercise Training

Behavioral

exercise training min. 4 times a day for at least 30 min

Intensive exercise training

Behavioral

Intensive exercise training for 4 times / day incl. interval training at 95% individual threshold

Primary outcomes

  1. coronary collateral blod flow

    Time frame: 4 weeks

Secondary outcomes

  1. plaque composition within the coronary artery

    Time frame: 4 weeks

    plaque composition measured by virtual histology intravascular ultrasound

  2. MACCE

    Time frame: 4 week, 6 months, 12 months

    major cardiovascular events (death, myocardial infarction, stroke, TIA, coronary revascularisation, hospitalisation)

  3. atherosclerosis parameter within the laboratory

    Time frame: 4 weeks, 3, 6, 12 months

    e.g. wie hs-CRP, HDL, LDL, ges. Cholesterin, Triglyceride, Zytokine, Adipokine, Endocannaboide

Sponsors and collaborators

Lead sponsor

University of Leipzig

Other

Registry information

Official study title

Impact of Intensive Exercise Training Compared to Inactive Controls on Coronary Collateral Circulation and Plaque Composition in Patients With Significant Stable Coronary Artery Disease

Important dates

Study start
2010
Primary completion
2012
Study completion
2012
First posted
Sep 27, 2010
Registry last updated
Oct 26, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.