University of Leipzig Medical Center
Leipzig, 04103, Germany
Completed
NCT Number: NCT04963400
Impact of Hospitalization on High-sensitivity Cardiac Troponin T Concentrations Depending on Disease Severity
We aim to examine, whether hospitalization is associated with higher high-sensitivity cardiac troponin T (hs-cTnT) serum concentrations in patients without a cardiac disease.
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Notify MeKey information
Conditions
Age range
50 year and older
Sex eligibility
All sexes
Study type
Observational
Primary location
About this study
High-sensitivity cardiac troponin T (hs-cTnT) values will be obtained in hospitalized patients a) without a diagnosed or suspected cardiac disease, and b) with an acute medical condition that is not commonly associated with an increase of hs-cTnT concentrations. As a reference, a second sampling of blood for an analysis of the hs-cTnT serum concentration will be obtained in the same patients after discharge (60 days after hospitalization).
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- hospitalization due to a non-cardiac disease
- age ≥ 50 years
Exclusion criteria
- diagnosed or suspected cardiac disease
- acute medical conditions commonly associated with a myocardial injury (e.g. circulatory shock, sepsis, pulmonary embolism, cerebral infarction, acute renal failure)
Treatment and study plan
Analysis of hs-cTnT serum concentration at hospitalization
Diagnostic TestAnalysis of the hs-cTnT serum concentration in the blood drawn at the day of hospitalization
Analysis of hs-cTnT serum concentration after discharge
Diagnostic TestAnalysis of the hs-cTnT serum concentration in the blood drawn after discharge (60 days after hospitalization)
Primary outcomes
-
Difference of the hs-cTnT concentration at hospitalization and after discharge
Time frame: 60 days
Secondary outcomes
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Difference of the hs-cTnT concentration at hospitalization and after discharge in acute medical conditions of low severity
Time frame: 60 days
-
Difference of the hs-cTnT concentration at hospitalization and after discharge in acute medical conditions of medium severity
Time frame: 60 days
-
Difference of the hs-cTnT concentration at hospitalization and after discharge in acute medical conditions of high severity
Time frame: 60 days
-
Prediction of 1-year-mortality by hs-cTnT concentration
Time frame: 1 year
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Prediction of 1-year-hospitalization rate due to a cardiovascular disease by hs-cTnT concentration
Time frame: 1 year
Sponsors and collaborators
Lead sponsor
University of Leipzig
Other
Registry information
Official study title
Impact of Hospitalization on High-sensitivity Cardiac Troponin T Concentrations Depending on Disease Severity (Inpatient Troponin T)
Important dates
- Study start
- 2021
- Primary completion
- 2024
- Study completion
- 2024
- First posted
- Jul 15, 2021
- Registry last updated
- Apr 3, 2024
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.