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NCT Number: NCT03673644

Impact of Glaucoma and Visual Field Loss on Life Space

Mobility refers to a person's purposeful movement through the environment from one place to another and can be conceptualized as a continuum from bed bound (immobility) on one extreme to making excursions to distant locations on the other extreme. Primary open-angle glaucoma (POAG) is a chronic, progressive optic neuropathy that can lead to gradual loss of vision in the peripheral field and central vision. Older adults with POAG have an increased risk for motor vehicle collisions and falls. Moreover, existing studies suggest that patients with POAG exhibit more postural sway while standing as measured by a balance platform and also tend to walk more slowly than those who are normally sighted and free of ocular disease. While these disturbances likely influence mobility, there has been little research directly assessing the impact of POAG on mobility. This study will assess the impact of POAG on life space (one aspect of mobility) and will determine whether difficulties with life space are associated with difficulties experienced under conditions of dim lighting.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Primary Open-Angle Glaucoma Eye Diseases Glaucoma Glaucoma, Open-Angle Ocular Hypertension

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Alabama at Birmingham

Birmingham, Alabama, 35294, United States

About this study

Aim 1: To examine the extent of life space in older adults with POAG using the Life Space Questionnaire and to examine whether life space in persons with POAG is associated with the magnitude of visual field impairment.

Aim 2: To examine difficulties seeing under dim illumination and at night in older adults with POAG using the Low Luminance Questionnaire and to examine whether greater difficulty in seeing under dim illumination and at night is related to the magnitude of visual field loss.

Aim 3: To examine the relationship in older adults with POAG between visual problems seeing under dim illumination and at night (Low Luminance Questionnaire) and their life space (Life Space Questionnaire).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of primary open-angle glaucoma
  • Best-corrected visual acuity of 20/40 or better
  • Spherical refraction within ± 5 Diopters
  • Cylinder refraction within ± 3 Diopters

Exclusion criteria

  • History of intra-ocular surgery other than uncomplicated cataract or glaucoma surgery
  • Significant cognitive impairment

Treatment and study plan

questionnaires

Other

Two questionnaires will be administered, one focusing on life space and the other focusing on low luminance.

Primary outcomes

  1. Assessment of life space measured with the Life Space Questionnaire

    Time frame: Day one

    The Life Space Questionnaire is a 9-item questionnaire that assesses how much a person gets out and about and the spatial extent of the person's typical life space, i.e., what is the usual range of places in which the person engages in activities within the designated time frame. Patients are asked to respond either Yes or No.

Secondary outcomes

  1. Relationship between the Life Space Questionnaire and vision loss

    Time frame: Day one

    The results obtained on the Life Space Questionnaire will be correlated with the results of the visual field tests

  2. Assessment of vision under dim illumination and at night using the Low Luminance Questionnaire

    Time frame: Day one

    The Low Luminance Questionnaire is a 32-item questionnaire that assesses problems that involve vision under different lighting conditions or feelings about vision under different lighting conditions. The range of responses is different for different questions, with the overall pattern being that "1" means "No difficulty at all" and that increasingly higher numbers mean increasingly more difficulty.

  3. Relationship between Low Luminance Questionnaire and vision loss

    Time frame: Day one

    The results obtained on the Low Luminance Questionnaire will be correlated with the results of the visual field tests.

  4. Relationship between the Low Luminance Questionnaire and the Life Space Questionnaire

    Time frame: Day one

    The results of the Low Luminance Questionnaire will be correlated with the results of the Life Space Questionnaire

Sponsors and collaborators

Lead sponsor

University of Alabama at Birmingham

Other

Collaborators

  • National Institute on Aging (NIA)

Registry information

Official study title

Glaucoma, Visual Field Loss, and Their Association With Life Space in Older Adults

Important dates

Study start
2018
Primary completion
2019
Study completion
2026
First posted
Sep 17, 2018
Registry last updated
Sep 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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