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NCT Number: NCT07313293

Impact of Foot Reflexology on Nausea After Obesity Surgery

Obesity is a major public health issue. The Obépi epidemiological survey, the results of which were published in 2020, shows a steady increase in obesity among the French population.

Currently, more than 23 million French people are overweight or obese, and more than 8 million French people are obese. The most effective treatment currently available is surgery. These procedures are governed by specific recommendations. Between 50,000 and 60,000 procedures are performed in France each year. Three procedures are authorised: gastric banding, sleeve gastrectomy and gastric bypass.

Hallyday & al report 65% of patients experiencing nausea/vomiting after bariatric surgery. In 2019, Suh & al showed that nausea and vomiting were more common after sleeve gastrectomy and that they were responsible for an increase in the length of hospitalisation. These episodes of nausea and vomiting occur within 48 hours after sleeve gastrectomy and can cause difficulties in resuming eating. One of the factors contributing to the occurrence of nausea and vomiting was the use of opioids.

The benefits of foot reflexology were reported in 2023 by Dr Carrazé in rectal surgery. His doctoral thesis in medicine showed that foot reflexology sessions on days 1, 2 and 3 following rectal surgery reduced post-operative ileus and post-operative pain. The reduction in post-operative ileus led to a decrease in episodes of nausea and vomiting.

In 2021, Murat-Ringot & al demonstrated the beneficial effect of foot reflexology on nausea and vomiting during chemotherapy sessions, in addition to the anti-emetic treatments used for prevention. Anderson & al. in 2021 also demonstrated a beneficial effect on pain in cancer patients, with no effect on nausea.

The principle of foot reflexology is based on the fact that each organ, gland or part of the body corresponds to a reflex zone on the foot, hand, ears or face. Stimulation of the reflex zones is thought to activate the autonomic nervous system. Currently, there is very little scientific evidence on how this practice works and what its effects are. Despite various scientific publications on the results of foot reflexology, scientific evidence of its effectiveness remains weak. Only one prospective randomised trial has been found in the literature (Dalal & al.) on the quality of life of patients with epilepsy.

Despite the lack of high-quality studies, it appears that foot reflexology could benefit patients by reducing nausea and vomiting. To date, no studies have evaluated its effectiveness in the post-operative period, particularly after bariatric surgery.

The aim of our randomised trial is to evaluate the impact of foot reflexology on nausea and vomiting after sleeve gastrectomy.

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Key information

Conditions

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Centre Hospitalier Départemental Vendée

La Roche-sur-Yon, 85000, France

Location status: Recruiting

Location contact

Emeric ABET

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult patient
  • Patient scheduled to undergo sleeve gastrectomy
  • Patient capable of understanding the protocol and having given their informed verbal consent to participate in the study
  • Patient affiliated with the social security system or entitled to benefits

Exclusion criteria

  • Patients receiving long-term morphine and opioid treatment
  • Patients with phlebitis, a wound under the foot, or recent foot trauma (cast immobilisation, splint, etc.)
  • Patients under guardianship, curatorship, or deprived of their liberty
  • Patients who are pregnant, breastfeeding, or refusing contraception
  • Patients participating in another clinical research protocol that has an impact on the objective of the study
  • Patients under an activated future protection mandate
  • Patients under family authorisation
  • Patients under judicial protection

Treatment and study plan

Foot reflexology

Other

Foot reflexology sessions to:

  • Prepare the body and mind for surgery
  • Promote physical and nervous relaxation
  • Relieve post-operative nausea and vomiting

Primary outcomes

  1. Number of patients experiencing significant nausea and/or vomiting (with a score ≥ 3 on a numerical scale of 0 to 10) within 24 hours post-operatively

    Time frame: 24 hours post-operatively

    A score of ≥ 3 corresponds to the introduction of treatment.

Study contacts

Contact information is provided by the study sponsor or research team.

Chloé MOREAU

CONTACT

[email protected]

251446327 ext. +33

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Departemental Vendee

Other

Registry information

Acronym: IRANNO

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Dec 31, 2025
Registry last updated
Apr 2, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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