Impact of Fluid Resuscitation on Venous Congestion in Cardiac Critically-ill Patients

The objective of this study is to assess how fluid resuscitation, in the context of fluid responsiveness, affects the incidence and progression of systemic venous congestion in critically ill cardiac patients. Additionally, the study aims to evaluate the impact on clinical outcomes, with a particular focus on acute kidney dysfunction. This assessment will utilize the VExUS score in conjunction with comprehensive bedside echocardiographic evaluations.

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Key information

Conditions

Cardiac and Aortic Surgery Cardiac Anaesthesia Cardiovascular Diseases Fluid Resuscitation Hyperemia Vascular Diseases Venous Congestion

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age above 18 years
Admission to cardiac intensive care unit

Treatment and study plan

VExUS & Cardiac Ultrasound

Diagnostic Test

The VExUS system provides a semi-quantitative assessment of systemic venous congestion by integrating ultrasound evaluations of the inferior vena cava diameter, hepatic vein flow, portal pulsatility, and renal venous flow, offering a practical and comprehensive bedside tool

Primary outcomes

Venous congestion

Time frame: 7 days

Venous congestion as assessed by the VExUS score at ICU admission, and on each of the first seven postoperative days.
Acute kidney injury

Time frame: Twenty-eight days

Acute kidney injury (AKI), defined through the KDIGO criteria, within seven and twenty-eight days of ICU admission.

Study contacts

Contact information is provided by the study sponsor or research team.

Pedro D Wendel Garcia, Dr. med.

CONTACT

[email protected]

+4369981577596

Sponsors and collaborators

Lead sponsor

Medical University of Vienna

Other

Registry information

Acronym: VExUS-CS

Important dates

Study start: 2025
Primary completion: 2027
Study completion: 2027
First posted: Sep 19, 2025
Registry last updated: Sep 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed