Impact of Fish Oil Supplementation in 3rd Trimester of Pregnancy on Maternal and Offspring Health

The aim of the trial is to investigate the effect of daily supplementation with 2.7 grams of long chain n-3 fatty acids during the third trimester of pregnancy. In 1990, 533 pregnant women, while they were in gestational week 30, were randomized to fish oil supplements providing the mentioned amount of long chain n-3 fatty acids, olive oil supplements, or no supplements; they were asked to take the supplements until delivery. Health outcomes were assessed during pregnancy and delivery. Further, offspring health and development has been examined during the ensuring two decades by making linkages to the rich Danish health and administrative registries, by asking the offspring to complete web-based questionnaires, and by examining the offspring physically.

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Key information

Conditions

Preterm Delivery Asthma Atopy Birth Weight Body Weight Bronchial Diseases Female Urogenital Diseases and Pregnancy Complications Glucose Metabolism Disorders Hyperinsulinism Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Insulin Resistance Lung Diseases Lung Diseases, Obstructive Metabolic Diseases Metabolic Syndrome Nutrition Disorders Nutritional and Metabolic Diseases Obesity Obstetric Labor Complications Obstetric Labor, Premature Overnutrition Overweight Pathological Conditions, Signs and Symptoms Pregnancy Complications Premature Birth Respiratory Hypersensitivity Respiratory Tract Diseases Signs and Symptoms Urogenital Diseases

Age range

20 year–50 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Aarhus University Hospital

Aarhus, DK-8000, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy pregnant women in gestation week 30

Exclusion criteria

Bleeding episodes during pregnancy

Treatment and study plan

Fish Oil

Dietary Supplement

4 1-g gelatine capsules per day providing 2,7 grams long chain n-3 fatty acids

Other names: Pikasol

Olive Oil

Dietary Supplement

4 1-g gelatine capsules with virgin olive oil

Primary outcomes

Gestation length

Time frame: 1989-1990 (1 year)

We assesed impact of fish oil supplementation in pregnancy on timing of spontaneous delivery

Sponsors and collaborators

Lead sponsor

Centre for Fetal Programming, Denmark

Other

Collaborators

Danish Council for Independent Research
EU Commision, DG12
Lundbech Foundation
National Institutes of Health (NIH)
The Danish Council for Strategic Research

Registry information

Important dates

Study start: 1989
Primary completion: 1990
Study completion: 2011
First posted: May 16, 2011
Registry last updated: Feb 28, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed