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OpenTrials
Active, Not Recruiting

NCT Number: NCT05744960

Impact of Financial Incentives

This trial will look at the impact of clinic-level financial incentives to improve provider communication and increase HPV vaccine uptake. Some clinics will receive communication training. Other clinics will receive the same training and a clinic-level financial incentive program with a monthly data feedback report to increase HPV vaccine uptake.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Human Papilloma Virus

Age range

9 year–12 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of North Carolina at Chapel Hill

Chapel Hill, North Carolina, 27599-7590, United States

About this study

The researchers will conduct a cluster randomized control trial. This trial will look at the impact of clinic-level financial incentives to improve provider communication and increase HPV vaccine uptake. The recruitment goal for the trial is 34 clinics in healthcare systems, including 9 rural-serving clinics. The researchers will randomize clinics using simple randomization (1:1). Some clinics will receive communication training. Other clinics will receive the same training and a clinic-level financial incentive program with a monthly data feedback report to increase HPV vaccine uptake. The researchers will use medical record data to compare changes in HPV vaccination among children ages 9-12. Clinics will be followed for 24 months. The study will engage clinical staff. Researchers will not have direct contact with children or their families.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

This trial will enroll clinics and intervene with clinical staff. We will use vaccination data from children to evaluate intervention effectiveness. We will not enroll children or interact with them directly.

Inclusion criteria

Clinics are eligible if they are a pediatric or family medicine clinic in North Carolina that in the past year had:

  • less than 72% HPV vaccine initiation rate,
  • greater than or equal to 50 patients ages 9-12
  • greater than or equal to 2 HPV vaccine providers
  • no clinic or provider-level financial incentive programs to increase system, clinic, or provider HPV vaccination rates among patients aged 9-12 in the past two years, and
  • no HPV vaccine provider communication trainings in the past six months.

Children's medical records will be eligible to be included in the dataset if children:

  • are between the ages of 9-12 years at baseline and
  • are attributed to a participating clinic at 12- or 24-month follow-up.

Exclusion criteria

Clinics are excluded if they:

  • do not provide HPV vaccine to children ages 9-12
  • have a specialty other than pediatrics or family medicine
  • had an HPV vaccine-specific financial incentive program in the past two years
  • had a formal HPV vaccine communication training in the past 6 months
  • had an HPV initiation rate greater than 72$
  • had fewer than 49 patients aged 9-12
  • had 1 or fewer HPV vaccine providers

Children's medical records will not be eligible to be included in the dataset if children:

  • are not between the ages of 9-12 years at baseline
  • are not attributed to a participating clinic at 12- or 24-month follow-up

Treatment and study plan

communication training

Behavioral

Clinics will host an Announcement Approach Training (AAT) workshop. A trained facilitator will use a standard script and slides to deliver workshop in-person or over Zoom; clinical staff who are unavailable will take the workshop later on their own.

Financial incentive

Behavioral

Clinics will host an AAT workshop, as in the other trial arm. Clinics in the intervention arm will then receive a 12-month clinic-level financial incentive program with predetermined targets for HPV vaccine initiation rates (5%, 10%, and 30% increases from baseline). Clinics will be notified of their HPV vaccination rates though a monthly, automated report. Clinic achievement will be assessed and incentives will be paid out to clinics monthly. Incentives will be tiered based on target and sized based on the number of clinic providers. For reaching the highest tier of 30%, clinics will receive an aggregate of $1000 per provider.

Primary outcomes

  1. HPV vaccination (≥1 dose), 9-12 year olds

    Time frame: from baseline to 12 months

    Proportion of unvaccinated children who initiate the HPV vaccine series between baseline and 12-month follow-up, among those who were ages 9-12 at baseline.

Secondary outcomes

  1. HPV vaccination (≥1 dose), 9-12 year olds

    Time frame: from 13 months to 24 months

    Proportion of unvaccinated children who initiate the HPV vaccine series between 13- and 24-month follow-up, among those who were ages 9-12 at 13 months.

  2. HPV vaccination (≥2 doses), 9-12 year olds

    Time frame: from baseline to 12 months

    Proportion of unvaccinated children who complete the HPV vaccine series between baseline and 12-month follow-up, among those who were ages 9-12 at baseline.

  3. HPV vaccination (≥2 doses), 9-12 year olds

    Time frame: from 13 months to 24 months

    Proportion of unvaccinated children who complete the HPV vaccine series between 13- and 24-month follow-up, among those who were ages 9-12 at 13 months.

Sponsors and collaborators

Lead sponsor

UNC Lineberger Comprehensive Cancer Center

Other

Collaborators

  • National Cancer Institute (NCI)

Registry information

Official study title

The Impact of Clinic-level Financial Incentives on HPV Vaccine Communication and Uptake

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Feb 27, 2023
Registry last updated
Jun 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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