Impact of Early Antibiotics on Non-Traumatic Out of Hospital Cardiac Arrest (OHCA)

As above

Inclusion criteria

• ● Adults aged >18 years, presenting to HGH ED after out-of-hospital cardiac arrest

• Patients with low likelihood of infection as per the definitions provided above
• Ability to obtain informed consent from the subjects or their next of kin/family member/legal surrogate in case of incapacitation due to sedation, mechanical ventilation, etc. In case the next of kin is not available, an independent physician who is not a part of the investigative team will complete and sign the checklist as per HMC Policy "RES 11026_Appendix 6.5". (see section 4.1.3 for details) A member of the investigative team and a witness will also sign this form before the potential subject is enrolled in the study.

Exclusion criteria

• Patients who have clear evidence of infection, as defined by criteria for the study.

• Patients who have received antibiotics within the last 1 week prior to admission.
• Patients with malignancy, except those who have been cured or in complete remission.
• Females with known pregnancy.
• Known immunocompromised states (including HIV/AIDS, transplant recipients on immunosuppressant drugs, long-term [> 3 weeks of prednisone >5mg/day equivalent] steroid therapy).
• Patients on immunologic disease modifying agents (commonly known as "biologics")
• Patients considered "brain-dead" or "vegetative state"
• Patients transferred from another hospital, long term care facility or institution
• Neutropenia (total WBC <1,500/mm3 or absolute neutrophil count of <1,000/mm3)