Skip to main content
OpenTrials
Active, Not Recruiting

NCT Number: NCT04972513

Impact of E-cigarette Use on the Body

This study examines how electronic (e)-cigarette use impacts the body, by studying both users and non-users of e-cigarettes. Early evidence indicates that e-cig users experience adverse health effects. Results of this study may help policy-makers develop standards for different types of tobacco.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Notify Me

Key information

Conditions

Cigarette Smoking-Related Carcinoma

Age range

15 year–25 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210, United States

About this study

PRIMARY OBJECTIVE:

Examine the short-term impacts of vaping on pulmonary and respiratory outcomes.

OUTLINE:

Current e-cigarette users will vape their own e-cigarette device ad libitum for 30 minutes; non-users will watch a neutral video for 30 minutes. Before and after the 30 minute vaping [video] session, participants will undergo the following assessments: computer-based spirometry testing, nitric oxide breath testing, airwave oscillometry, and an assessment of endothelial function. Participants will also undergo collection of blood.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 75 e-cig users and 75 never-users
  • No self-reported diagnosis of lung disease (e.g., coronavirus disease-2019 [COVID-19], pneumonia, cystic fibrosis)
  • No history of cardiac event or distress
  • Not currently breastfeeding, pregnant, or planning to become pregnant (e-cig users only; will be confirmed via pregnancy test)

Treatment and study plan

Biospecimen Collection

Procedure

Undergo collection of blood

Nitric Oxide Breath Test

Procedure

Undergo nitric oxide breath testing

Oscillometry

Procedure

Undergo airwave oscillometry

Spirometry

Procedure

Undergo spirometry

Survey Administration

Other

Complete survey

Endothelial function

Procedure

Endothelial function will be assessed with the EndoPAT device, which measures changes in pressure from sensors placed on the fingertip

Primary outcomes

  1. Airway inflammation as assessed by exhaled nitric oxide

    Time frame: Procedure will last approximately 3 minutes; the procedure will occur twice during the laboratory session (separated by approximately 60 minutes)

    Exhaled nitric oxide will be measured in parts per billion (ppb)

  2. Airway reactivity as assessed by airwave oscillometry

    Time frame: Procedure will last approximately 3 minutes; the procedure will occur twice during the laboratory session (separated by approximately 60 minutes)

    Airway reactivity will be measured via Tremoflo, which is a well validated measurement of airway reactivity and provides curves of Resistance (R) and Reactance (X)

  3. Respiratory functioning as assessed by a mobile Spirometry device

    Time frame: Procedure will last approximately 3 minutes; the procedure will occur twice during the laboratory session (separated by approximately 60 minutes)

    Spirometry will collect daily data from participants on the relationship between their forced expiratory volume and forced vital capacity (measured as FEV1/FVC).

  4. Endothelial function

    Time frame: Procedure will last approximately 20 minutes; the procedure will occur twice during the laboratory session (separated by approximately 90 minutes)

    Endothelial function will be assessed with the EndoPAT device (unit of measurement = LnRHI).

Sponsors and collaborators

Lead sponsor

Ohio State University Comprehensive Cancer Center

Other

Registry information

Official study title

The Emerging Adulthood Health Project

Important dates

Study start
2021
Primary completion
2022
Study completion
2026
First posted
Jul 22, 2021
Registry last updated
Mar 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.