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OpenTrials
Completed

NCT Number: NCT03844672

Impact of E-cigarette Characteristics on Reinforcement and Tobacco Use Patterns

The purpose of this project is to understand how different e-cigarettes influence their likeability and use among current smokers who try using e-cigarettes. Participants will receive an e-cigarette to sample over a three week period. During this time period they will complete daily electronic diaries and weekly lab visits. The results from this information will help understand how different types of e-cigarettes are likely to influence cigarette and e-cigarette use.

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Key information

Conditions

Smoking Behavior Tobacco Use

Age range

21 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Medical University of South Carolina

Charleston, South Carolina, 29425, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

include

  • adults who have been smoking daily
  • interested in using e-cigarettes
  • who have a smartphone that can receive text messages and access to the internet or has an e-mail account that they check daily

Exclusion criteria

include

  • minimal prior e-cigarette use
  • use of tobacco products other than cigarettes
  • current use of cessation medications
  • pregnant, trying to become pregnant, or breastfeeding,
  • recent history of cardiovascular distress in the last three months (e.g., arrhythmia, heart attack, stroke, uncontrolled hypertension),
  • household member currently enrolled in the study.

Treatment and study plan

Low Power

Behavioral

Participants will receive a low power e-cigarette to use for 3 weeks

High Power

Behavioral

Participants will receive a high power e-cigarette to use for 3 weeks

Low Concentration

Behavioral

Participants will receive a low concentration e-liquid to use for 3 weeks

High Concentration

Behavioral

Participants will receive a high concentration e-liquid to use for 3 weeks

Primary outcomes

  1. Mean Cigarettes Per Day

    Time frame: Week 3

    Participants complete weekly surveys reporting the number of cigarettes smoked each day on a continuous scale

Secondary outcomes

  1. Average Number of E-cigarette Puffing Episodes

    Time frame: Week 3

    Participants complete weekly surveys reporting the number of e-cigarette puffing episodes each day on a continuous scale

  2. Number of Choices to Smoke Cigarette in Lab Setting

    Time frame: Week 3

    Participants complete lab-based choice task at Week 3 visit in which they choose between smoking conventional cigarette and e-cigarette over 10 trials. Outcome is number of times each participant chooses to smoke conventional cigarette.

Sponsors and collaborators

Lead sponsor

Medical University of South Carolina

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Impact of E-cigarette Characteristics on Reinforcement and Tobacco Use Patterns Among

Important dates

Study start
2019
Primary completion
2023
Study completion
2023
First posted
Feb 18, 2019
Registry last updated
Oct 24, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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