Impact of Different CRRT Modalities, Dosing Strategies, and Timing on Kidney Recovery and Prolonged Kidney Dysfunction

KARMA study is a hospital-based research study looking at how different ways of delivering kidney support therapy (CRRT) affect patients who are critically ill. In some cases, the kidneys may temporarily stop working in very sick patients, and machines are used to filter the blood. This study is exploring whether the way the investigators use these machines - how early to start, how much treatment to give, and what type to choose - makes a difference in how well the kidneys recover. By learning from many hospitals and hundreds of patients, KARMA hopes to improve treatment choices and help patients regain their kidney function faster.

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Key information

Conditions

Acute Kidney Disease Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Acute kidney injury
ICU administration

Exclusion criteria

Pre-existing CKD (GFR < 30 ml/min/1,73m2)
Chronic dialysis-dependent end-stage renal failure

Treatment and study plan

Continuos renal replacement therapy

Device

Different modalities of CRRT: continuous veno-venous hemofiltration; continuous veno-venous hemodialysis and continuous veno-venous hemodiafiltration Different doses of CRRT: low effluent dose (<15 ml/kg/h); medium-low effluent dose (15-25 ml/kg/h); standard effluent dose (25-30 ml/kg/h); high effluent dose (>30 ml/kg/h

Primary outcomes

Percentage of patients with AKD

Time frame: 90 days

Percentage of patients with AKD divided by subgroups regarding AKI etiology

Secondary outcomes

Durations and severity of AKD, free days of CRRT and kidney recovery

Time frame: 90 days

AKD duration in days AKD severity described and compared by AKI stages Patients with AKD divided by subgroups regarding indication for CRRT (fluid overload, electrolyte disturbances, metabolic acidosis, uremia, oliguria/anuria) and CRRT dose (ml/kg/hour) CRRT free days during ICU Kidney recovery/stage of CKD/dialysis dependency

Sponsors and collaborators

Lead sponsor

Croatian Society for Organ Support

Other

Registry information

Official study title

A Multicentric Observational Study Examining How Different CRRT Modalities, Dosing Strategies, and Timing Impact Kidney Recovery and the Development of Prolonged Kidney Dysfunction (Acute Kidney Disease) in Critically Ill Patients

Acronym: KARMA

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Jul 4, 2025
Registry last updated: Jul 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed