Impact of Dietary Patterns on Prognosis of Ovarian Cancer Patients During PARPi Maintenance

Inclusion criteria

• Female patients aged 18 to <75 years.
• Histologically or cytologically diagnosed with primary high-grade serous ovarian cancer (HGSOC), fallopian tube cancer, or primary peritoneal cancer.
• Received initial tumor cytoreductive surgery (Primary Debulking Surgery or Interval Debulking Surgery) and first-line platinum-based chemotherapy, achieving Complete Response (CR) or Partial Response (PR).
• Received PARP inhibitors as maintenance therapy for the first time following the completion of first-line treatment.
• Complete clinical data available in the electronic medical records, including baseline characteristics, first-line treatment details, PARPi maintenance therapy information, and prognostic follow-up data.
• The patient (or primary caregiver) has normal communication abilities, voluntarily agrees to participate, and is able to cooperate in completing the retrospective Food Frequency Questionnaire (FFQ).

Exclusion criteria

• Clinical diagnosis only, without pathological or cytological confirmation.
• Non-high-grade serous histological subtypes (e.g., ovarian clear cell carcinoma, endometrioid carcinoma, mucinous carcinoma, low-grade serous carcinoma).
• Secondary or metastatic ovarian cancer (malignancy originating from other organs).
• Severe deficiency of key clinical or prognostic information that prevents assessment of the primary endpoint.
• Inability to accurately recall dietary information due to cognitive impairment, mental illness, or other reasons.
• Presence of severe metabolic or digestive system diseases during PARPi maintenance therapy that required specific restricted diets (e.g., insulin-dependent diabetes, dialysis-dependent renal insufficiency, short bowel syndrome, active Crohn's disease).
• Occurrence of significant physiological events during the study period that significantly altered dietary structure (e.g., major gastrointestinal surgery).