Impact of COVID-19 Pandemic and Social Distancing on Mental Health of Chronic Inflammatory Rheumatism Affected Patients

The previous H1N1 and SRAS-1 pandemics, that required to containment and quarantine, have lead to the emergence of mental symptoms such as stress, anxiety, insomnia… The French COCONEL study during the COVID pandemic have shown the major psychological impact of this crisis on the population, leading to stress and fears.

Stressful life events are well-known factors of chronic inflammatory rheumatisms set-up or flare. The aim of this study is therefore to evaluate the psychological impact of COVID-19 pandemic on chronic inflammatory rheumatism (CIR) affected patients.

A case-control prospective multicentric study will be performed on 212 CIR patients versus 106 controls to compare the stress level in each group. Patient reported outcomes will be evaluated, using electronic questionnaires, as well as classical clinical informations on CIR evolution during a 6-months follow-up period. An ancillary study on 100 patients will also be realized to quantify cytokine serum levels and determinate transcriptomic profiles.

For the cases:

Inclusion criteria

• adult patient (age over 18 years old)
• patient affected by a chronic inflammatory rheumatism (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Systemic lupus, Still disease, scleroderma…)
• patient without any language difficulty
• affiliated to an health insurance system
• and who agree to participate in the study

For controls :

Inclusion criteria

• adult patient (age over 18 years ol
• patient affected by a non-inflammatory or degenerative musculo-skeletal disease during the containment period,
• patient without any language difficulty,
• affiliated to an health insurance system,
• and who agree to participate in the study.

For cases and controls :

Exclusion criteria

• pregnant or lactating patient
• psychiatric patient
• patient under guardianship or other legal protection regimen.