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OpenTrials
Completed

NCT Number: NCT02154607

Impact of Continuous Defocused CO2 Laser Vaporisation on the Histological Malignant Transformation of Erosive Oral Lichen Planus in Patients

Oral Lichen Planus (OLP) is a common condition with its erosive variant occasionally presenting a management challenge to the clinician. In addition it can have debilitating consequences on the patients' quality of life. The malignant transformation of OLP has been well documented. The aims of this work were to measure the number of patients developing malignant transformationof OLP to squamous cell carcinoma (SCC) comparing patients undergoing traditional symptomatic treatments with those patients that were treated by CO2 laser from 2004 - 2011. Outcome measures were rated by incisional biopsy (histology Report).

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Key information

Conditions

Oral Lichen Planus Disease Attributes Lichen Planus Lichen Planus, Oral Lichenoid Eruptions Mouth Diseases Neoplasms Pathologic Processes Pathological Conditions, Signs and Symptoms Recurrence Skin Diseases Skin Diseases, Papulosquamous Skin and Connective Tissue Diseases Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Oral lichen planus
  • Histological confirmation of diagnosis
  • Patient willing for treatment

Exclusion criteria

  • Patient just does not want to participate as control/study group

Treatment and study plan

CO2-Laser Treatment

Device

Primary outcomes

  1. stable disease of OLP (clinical observation)

    Time frame: 1 year

Secondary outcomes

  1. Development of oral cancer (histological report after incisional biopsy)

    Time frame: 3 years

Other outcomes

  1. Development of reccurrence of OLP (clinical observation)

    Time frame: 3 years

Sponsors and collaborators

Lead sponsor

Technical University of Munich

Other

Registry information

Official study title

Clinical Trial Analyzing the Impact of Continuous Defocused CO2 Laser Vaporisation on the Histological Malignant Transformation of Erosive Oral Lichen Planus

Important dates

Study start
2004
Primary completion
2011
Study completion
2013
First posted
Jun 3, 2014
Registry last updated
Jun 3, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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