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OpenTrials
Completed

NCT Number: NCT02260206

Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion

The effects colchicine administration for acute pericardial effusion after radiofrequency catheter ablation (RFCA) of atrial fibrillation on the recurrences of arrhythmia.

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Key information

Conditions

Pericardial Effusion Cardiovascular Diseases Heart Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Seoul St Mary's Hospital

Seoul, Seo Cho Gu, 137-701, South Korea

About this study

RFCA was started as a rhythm control of atrial fibrillation about 10 years before and the superiority of RFCA to medical treatment has been continuously reporting, so RFCA is globally performed nowadays. Acute pericardial effusion could occur during RFCA as complication, that might be developed to cardiac tamponade needed immediate pericardiocentesis. The inflammation developed after pericardiocentesis might be associated with the recurrences of atrial fibrillation, it could be presumed by the frequent occurrence of atrial fibrillation after open-heart surgery. The inflammation can be suppressed by administration of colchicine and the effects of colchicine have been proven to decrease the development of atrial fibrillation.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients needed to pericardiocentesis during RFCA for paroxysmal or persistent atrial fibrillation.

Exclusion criteria

  • Hypersensitivity on Colchicine
  • The existence of intra-cardiac thrombus on trans-esophageal echocardiography
  • Pregnancy

Treatment and study plan

Colchicine

Drug

Impact of Colchicine therapy on arrhythmia Recurrence after Acute Pericardial Effusion following Catheter Ablation of Atrial Fibrillation

Other names: Impact of Colchicine

Primary outcomes

  1. recurrence of atrial arrhythimia

    Time frame: 1 year after colchicines administration

    Assessment of the recurrence of atrial arrhythimia 1 year after colchicines administration

Secondary outcomes

  1. recurrence of atrial arrhythimia

    Time frame: 3 year after colchicines administration

    Assessment of the recurrence of atrial arrhythimia 3 year after colchicines administration

Sponsors and collaborators

Lead sponsor

Yong Seog Oh

Other

Registry information

Official study title

Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion Following Catheter Ablation of Atrial Fibrillation

Important dates

Study start
2014
Primary completion
2019
Study completion
2023
First posted
Oct 9, 2014
Registry last updated
Apr 23, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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