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Completed

NCT Number: NCT03834831

Impact of Coenzyme Q10 and Selenium on Seminal Fluid and Semen Antioxidant Status

The study was conducted to assess the impact of coenzyme Q10 and selenium on seminal fluid parameters and antioxidant status in infertile men.

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Key information

Conditions

Male Infertility Genital Diseases Genital Diseases, Male Infertility Infertility, Male Male Urogenital Diseases Urogenital Diseases

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Fertility Unit, Babyl

Hillah, 00964, Iraq

About this study

The aim of this study was to assess the impact of coenzyme Q10 and selenium on seminal fluid parameters and antioxidant status in infertile men with idiopathic oligoasthenoteratospermia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • History of infertility of at least 12 months despite regular unprotected intercourse.
  • Oligoasthenoteratospermia was diagnosed by semen analysis showing abnormal sperm concentration (<15 million/ml), progressive motility (<32%), total motility (<40%) and morphology (<30% WHO criteria) as defined by WHO manual for semen analysis 2010

Exclusion criteria

  • Azoospermia,
  • Varicocele,
  • Genital tract infection,
  • Cryptorchidism,
  • Testicular trauma or scrotal surgery,
  • Endocrine disorder,
  • Systemic illness,
  • Smoking
  • The presence of female factor

Treatment and study plan

Coenzyme Q10

Dietary Supplement

Coenzyme Q10

Selenium

Dietary Supplement

Selenium

Primary outcomes

  1. Semen volume (WHO 2010 guidelines)

    Time frame: 3 months

    Semen volume in ml

  2. Sperm concentration in semen (WHO 2010 guidelines)

    Time frame: 3 months

    Sperm concentration in million/ml

  3. Sperm motility in semen (WHO 2010 guidelines)

    Time frame: 3 months

    Sperm motility (%)

  4. Sperm morphology in semen (WHO 2010 guidelines)

    Time frame: 3 months

    Normal sperm morphology (%)

  5. Seminal plasma TAC (Colorimetric assays)

    Time frame: 3 months

    Seminal plasma total antioxidant capacity in mmol/ml

  6. Seminal plasma CAT (Colorimetric assays)

    Time frame: 3 months

    Seminal plasma catalase in U/ml

  7. Seminal plasma SOD (Colorimetric assays)

    Time frame: 3 months

    Superoxide dismutase in U/ml

Sponsors and collaborators

Lead sponsor

University of Sumer

Other

Registry information

Official study title

Impact of Coenzyme Q10 and Selenium on Seminal Fluid Parameters and Antioxidant Status in Men With Idiopathic Infertility

Important dates

Study start
2018
Primary completion
2018
Study completion
2019
First posted
Feb 8, 2019
Registry last updated
Mar 14, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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