Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07425249

Impact of Chewing Gum on Postoperative Gut Motility in Gastrointestinal Surgery Patients

Postoperative ileus (POI) is a frequent complication after abdominal surgery, leading to delayed gastrointestinal motility, prolonged hospital stay, and increased patient discomfort. Chewing gum, as a form of sham feeding, has been proposed to stimulate gut motility through vagal stimulation and increased gastrointestinal secretions. This randomized controlled trial aims to assess the effect of chewing gum on early recovery of gastrointestinal motility in patients undergoing open gastrointestinal surgery.

Recruiting

Interested in participating?

Request Info

Key information

Age range

17 year–85 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Khyber Teaching Hospital

Peshawar, KPK, 25000, Pakistan

Location status: Recruiting

Location contact

Dr Ali Raza, MBBS

CONTACT

[email protected]

Dr Munir Ahmed, FCPS

CONTACT

[email protected]

About this study

This prospective randomized controlled trial will evaluate whether chewing gum reduces the time to return of bowel function after gastrointestinal surgery. Ninety-six adult patients undergoing open gastrointestinal surgery will be randomly allocated into intervention and control groups using block randomization. The intervention group will receive glucose-containing chewing gum starting six hours postoperatively. Outcomes measured include time to first bowel sounds, passage of flatus, and defecation. Statistical analysis will assess differences between groups to determine the efficacy of chewing gum in preventing postoperative ileus.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 17 and 85 years.
  • Patients of either gender.
  • Undergoing open gastrointestinal surgical procedures (elective or emergency).
  • Willing to participate and able to provide informed consent.

Exclusion criteria

  • Patients with metabolic or endocrine disorders (diabetes mellitus, hypothyroidism, or hyperthyroidism).
  • Patients with renal disease or electrolyte imbalance.
  • Patients with chronic constipation or neuromuscular disorders.
  • Patients with substance abuse or drug addiction.
  • Patients receiving medications affecting gut motility (calcium channel blockers or antiepileptic drugs).
  • Patients with dental prosthesis or undergoing laparoscopic gastrointestinal surgery.

Treatment and study plan

Chewing Gum

Behavioral

Participants will chew glucose/carbohydrate-containing chewing gum for 15 minutes, three times daily, starting 6 hours after surgery and continuing for 48 hours or until the first passage of flatus or stool, in addition to standard postoperative care.

Primary outcomes

  1. Time to First Passage of Flatus

    Time frame: Within 48 hours postoperatively

    Time interval (in hours) from the end of surgery to the first postoperative passage of flatus, assessed by patient self-report and clinical evaluation.

  2. Time to First Defecation

    Time frame: Within 48 hours postoperatively

    Time interval (in hours) from the end of surgery to the first postoperative bowel movement (defecation), assessed by patient self-report and clinical evaluation.

Study contacts

Contact information is provided by the study sponsor or research team.

Dr Ali Raza, MBBS

CONTACT

[email protected]

+923452479895

Dr Munir Ahmed, FCPS

CONTACT

[email protected]

+923339493884

Sponsors and collaborators

Lead sponsor

Khyber Medical University Peshawar

Other

Collaborators

  • Khyber Teaching Hospital

Registry information

Official study title

Impact of Chewing Gum on Postoperative Gut Motility in Gastrointestinal Surgery Patients: A Randomized Controlled Trial at Khyber Teaching Hospital, Peshawar, Pakistan

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Feb 20, 2026
Registry last updated
Feb 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.