Impact of Catheter Ablation of Ventricular Arrhythmias on Suboptimal Biventricular Pacing in Cardiac Resynchronization Therapy

Cardiac resynchronization therapy reduces mortality in patients with systolic heart failure and left bundle branch block. Reduced biventricular pacing can lead to therapy failure. Most effective mortality reduction was seen with a BiV pacing above 98%.

Reduced BiV pacing is a common phenomenon with potential impact on CRT-response and pts' prognosis. Frequent ventricular ectopy may be associated with attenuated benefit from CRT. The investigators sought to systematically assess the effect of ventricular arrhythmia treatment on BiV pacing.

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Key information

Conditions

Systolic Heart Failure Arrhythmias, Cardiac Cardiac Complexes, Premature Cardiac Conduction System Disease Cardiac Resynchronization Therapy Cardiovascular Diseases Heart Diseases Heart Failure Heart Failure, Systolic Pathologic Processes Pathological Conditions, Signs and Symptoms Reduced Biventricular Pacing Tachycardia Tachycardia, Ventricular Ventricular Premature Complexes Ventricular Tachycardia

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University Hospital Cologne

Cologne, North Rhine-Westphalia, 50937, Germany

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

reduced biventricular pacing <98% due to ventricular arrhythmia

Exclusion criteria

reduced biventricular pacing <98% due to other cause
age <18
pregnancy

Treatment and study plan

Catheter ablation of ventricular arrhythmia

Procedure

PVC or VT ablation

Intensified medical therapy

Drug

Dosage increase / new onset of Betablocker / medical antiarrhythmic medication according to guideline and clinical practice

Primary outcomes

Percentage of Biventricular pacing

Time frame: 3 month after intervention biventricular pacing (%) is routinely monitored

Influence of intervention (Ablation/medical treatment) on previously reduced biventricular pacing percentage (<98%). Biventricular pacing is measured in percentage of stimulation and is monitored at routine device interrogation.

Sponsors and collaborators

Lead sponsor

Universitätsklinikum Köln

Other

Registry information

Important dates

Study start: 2020
Primary completion: 2021
Study completion: 2021
First posted: Aug 22, 2019
Registry last updated: Nov 15, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed