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NCT Number: NCT07423195

Impact of Cannabis Use During Third Molar Surgery

This study is for people scheduled to have their wisdom teeth (third molars) removed and are going to receive drug through an IV to put them to sleep.

The researchers are studying two groups: one group of people who report using recreational marijuana/THC/cannabis and another group who report not using it. They want to look at how both users and non-users do during the tooth removal.

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Key information

Conditions

Cannabis Use Agnosia Marijuana Usage Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Perceptual Disorders Sedation and Analgesia Signs and Symptoms Wisdom Tooth

Age range

16 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Michigan School of Dentistry/ Oral and Maxillofacial Surgery

Ann Arbor, Michigan, 48109, United States

Location status: Recruiting

Location contact

Jennifer Lay-Luskin, MPhil, CCRC

CONTACT

[email protected]

734-763-5963

About this study

When the researchers look at how both users and non-users do during the tooth removal, they will look at things like: how much medicine you need to be put to sleep, your body's vital signs like your number of heart beats, your blood pressure, and how many time you breathe during a minute.

Researchers will ask you questions about your health. If you report using marijuana/THC/cannabis, a small hair sample (about 1 or 2 inches) or fingernail (about the thickness of two credit cards from all 10 fingers) will be taken before tooth removal to check the amount of marijuana/THC/cannabis in your body. These will be sent to a lab using a number and not your name to protect your privacy and your confidential information. Also, we may be able to use the teeth that we take out to check the levels. These teeth are usually thrown away after your tooth removal.

If you report not using marijuana/THC/cannabis, a urine sample will be collected before tooth removal for a quick test to check for marijuana/THC/cannabis. We will also have you fill out a questionnaire about your pain levels and cannabis/THC use if you use it.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Provide a signed and dated informed consent form.
  • Willing to comply with all study procedures and be available for the duration of the study.
  • Aged ≥ 16 years old.
  • Presence at least one mandibular 3rd molar
  • American Society of Anesthesiologists (ASA) physical status class I or II

Exclusion criteria

  • Pathology (cyst or tumor) associated with the third molar tooth;
  • Health comorbidities (BMI 40 and above, and severe cardiovascular disease);
  • Pregnancy or lactation
  • Anything that would place the individual at increased risk or preclude the individual's full compliance with or completion of the study.

Treatment and study plan

Primary outcomes

  1. Midazolam administered

    Time frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to thirty minutes after initial sedative drug administration

    Amount (mg) of midazolam administered during third molar removal surgeries utilizing deep (IV) sedation in patients who are cannabis users versus cannabis non-users. The amount of these medications is registered by the timing of each administration, as well as the total amount of each medication given throughout the procedure.

  2. Mean arterial pressure

    Time frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to 30 minutes after initial sedative drug drug administration.

    Measurements of mean arterial pressure (MAP - mmHG) at five time points during third molar removal surgeries utilizing deep (IV) sedation in patients who are cannabis users versus cannabis non-users. The five-time points are: baseline (TB), 5 minutes after initial sedative drug administration (T5), 10 minutes after drug administration (T10), 20 minutes after drug administration (T20), and 30 minutes after drug administration (T30). Measurements on the patient discharge information are included in the data.

  3. Heart rate

    Time frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to 30 minutes after initial sedative drug drug administration.

    Measurements of heart rate (HR - bpm) at five time points during third molar removal surgeries utilizing deep (IV) sedation in patients who are cannabis users versus cannabis non-users. The five-time points are: baseline (TB), 5 minutes after initial sedative drug administration (T5), 10 minutes after drug administration (T10), 20 minutes after drug administration (T20), and 30 minutes after drug administration (T30). Measurements on the patient discharge information are included in the data.

  4. Carbon dioxide level

    Time frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to 30 minutes after initial sedative drug drug administration.

    Measurements of carbon dioxide level (CO2 - %) at five time points during third molar removal surgeries utilizing deep (IV) sedation in patients who are cannabis users versus cannabis non-users. The five-time points are: baseline (TB), 5 minutes after initial sedative drug administration (T5), 10 minutes after drug administration (T10), 20 minutes after drug administration (T20), and 30 minutes after drug administration (T30). Measurements on the patient discharge information are included in the data.

  5. Ketamine administered

    Time frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to thirty minutes after initial sedative drug administration

    Amount (mg) of ketamine administered during third molar removal surgeries utilizing deep (IV) sedation in patients who are cannabis users versus cannabis non-users. The amount of these medications is registered by the timing of each administration, as well as the total amount of each medication given throughout the procedure.

  6. Fentanyl administered

    Time frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to thirty minutes after initial sedative drug administration

    Amount (mg) of Fentanyl administered during third molar removal surgeries utilizing deep (IV) sedation in patients who are cannabis users versus cannabis non-users. The amount of these medications is registered by the timing of each administration, as well as the total amount of each medication given throughout the procedure.

  7. Propofol administered

    Time frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to thirty minutes after initial sedative drug administration

    Description: Amount (mg) of propofol administered during third molar removal surgeries utilizing deep (IV) sedation in patients who are cannabis users versus cannabis non-users. The amount of these medications is registered by the timing of each administration, as well as the total amount of each medication given throughout the procedure.

  8. Respiratory rate

    Time frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to 30 minutes after initial sedative drug drug administration.

    Measurements of respiratory rate (RR - breaths per minute) at five time points during third molar removal surgeries utilizing deep (IV) sedation in patients who are cannabis users versus cannabis non-users. The five-time points are: baseline (TB), 5 minutes after initial sedative drug administration (T5), 10 minutes after drug administration (T10), 20 minutes after drug administration (T20), and 30 minutes after drug administration (T30). Measurements on the patient discharge information are included in the data.

  9. Oxygen saturation

    Time frame: The time frame spans the third molar removal surgery from baseline at surgery appointment to 30 minutes after initial sedative drug drug administration.

    Measurements of oxygen saturation level (O2 - %) at five time points during third molar removal surgeries utilizing deep (IV) sedation in patients who are cannabis users versus cannabis non-users. The five-time points are: baseline (TB), 5 minutes after initial sedative drug administration (T5), 10 minutes after drug administration (T10), 20 minutes after drug administration (T20), and 30 minutes after drug administration (T30). Measurements on the patient discharge information are included in the data.

Secondary outcomes

  1. Complications

    Time frame: From tooth removal start to end of study

    Describe and compare intraoperative complications and post-op complications between patients who regularly use cannabis and patients who do not use cannabis.

  2. Cannabis level

    Time frame: From enrollment until end of the study

    Correlate the amount of cannabis detected in the hair/nails/teeth before surgery with perioperative and postoperative outcomes in patients who regularly use cannabis.

  3. Depth of Sedation

    Time frame: From tooth removal start to end of tooth removal

    Compare the depth of sedation (ASA classification) measured every five minutes between patients who regularly use cannabis and those who do not

Study contacts

Contact information is provided by the study sponsor or research team.

Bradley Blitstein, DDS

CONTACT

[email protected]

734-936-0864

Jennifer A Lay-Luskin, MPhil, CCRC

CONTACT

[email protected]

Oral and Maxillofacial Surgery

Sponsors and collaborators

Lead sponsor

University of Michigan

Other

Registry information

Important dates

Study start
2026
Primary completion
2029
Study completion
2030
First posted
Feb 20, 2026
Registry last updated
Feb 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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