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Completed

NCT Number: NCT07451080

Impact of Anterior Clinoid Process Pneumatization on Optic Canal and Retinal Nerve Fiber Layer

This retrospective cohort study aims to evaluate the potential effects of anterior clinoid process (ACP) pneumatization on optic canal morphometry and retinal nerve fiber layer (RNFL) thickness. ACP pneumatization is an anatomical variation that may alter the morphology of the optic canal and potentially influence the optic nerve.

Patients aged 18-65 years with available head and neck computed tomography (CT) imaging and optical coherence tomography (OCT) examinations between August 2018 and July 2025 will be retrospectively reviewed. Optic canal length and diameter will be measured using CT images, and RNFL thickness parameters will be obtained from OCT records. Measurements will be compared between patients with and without ACP pneumatization.

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Key information

Conditions

Anterior Clinoid Process Pneumatization Optic Canal Morphometry Retinal Nerve Fiber Layer Thickness

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Fethi Sekin City Hospital

Elâzığ, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 to 65 years.
  • Availability of head and neck computed tomography (CT) imaging in the hospital archive.
  • Availability of optical coherence tomography (OCT) examination records in the hospital archive.
  • CT and OCT examinations performed between August 2018 and July 2025.

Exclusion criteria

  • Age <18 years or >65 years. History or evidence of diabetes mellitus. History or evidence of hypertension. Glaucoma. Any condition or diagnosis that may cause optic nerve pathology (e.g., optic neuritis, compressive optic neuropathy, optic atrophy, demyelinating disease affecting the optic nerve).

Inadequate image quality or incomplete CT/OCT data preventing reliable measurements.

Treatment and study plan

Primary outcomes

  1. Optic Canal Length

    Time frame: Baseline (retrospective review of CT images obtained between August 2018 and July 2025)

    Optic canal length measured on computed tomography (CT) images.

  2. Optic Canal Mean Diameter

    Time frame: Baseline (retrospective review of CT images obtained between August 2018 and July 2025)

    Optic canal mean diameter measured on computed tomography (CT) images.

  3. Retinal Nerve Fiber Layer (RNFL) Thickness

    Time frame: Baseline (retrospective review of OCT images obtained between August 2018 and July 2025)

    Peripapillary retinal nerve fiber layer thickness measured by optical coherence tomography (OCT).

Sponsors and collaborators

Lead sponsor

Elazıg Fethi Sekin Sehir Hastanesi

Other

Registry information

Official study title

Evaluation of the Effects of Anterior Clinoid Process Pneumatization on Optic Canal Morphometry and Retinal Nerve Fiber Layer Thickness Using Computed Tomography and Optical Coherence Tomography: A Retrospective Cohort Study

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Mar 5, 2026
Registry last updated
Mar 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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