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Completed

NCT Number: NCT01042834

Impact of Air Pollution on the Autonomic Nervous System Activity and the Presence of Sleep Apnea in Older Subjects

Impact of air pollution on the autonomic nervous system activity and presence of sleep apnea in older subjects.

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Key information

Conditions

Healthy Apnea Dyssomnias Nervous System Diseases Respiration Disorders Respiratory Tract Diseases Sleep Apnea Syndromes Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

60 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospices Civiles de Lyon, Lyon, France

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About this study

The relation between the air pollution and morbidity, cardiovascular mortality was increasing interest. Analyses show an increase of respiratory difficulty, but also cardiac deaths in the daytime when the atmospheric pollution was increased. It was demonstrated that health effects of ambient air pollution in subjects presenting cardiac or lung difficulty were important. Mechanisms show a possible relation to autonomic nervous system (ANS) deactivation and mortality. Particularly, the ageing and ANS reach would be more predictive of cardiovascular events. Thus, we suggest estimating in 60 healthy volunteers from 60 to 80 years old, the impact of the air pollution on the autonomic nervous system activity and sleep apnea consequences.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • reside in Lyon and Saint-Etienne cities
  • security social affiliated or beneficiary
  • information note signed

Exclusion criteria

  • heart rate disorders
  • pacemaker
  • tabacco addiction or second-hand smoke
  • morbid obesity (BMI > 30)
  • insulin-dependent diabetes
  • chronic disease on treatment
  • antiarrythmic treatments

Treatment and study plan

Air pollution study on healthy volunteers.

Other

The subjects are examined three times:

  • First the volunteers get used to equipments.
  • Second and third the volunteers sleep in a pollution or purified air.

Other names: physiopathologic study

Primary outcomes

  1. Frequency analysis of heart rate variability

    Time frame: inclusion, 1 test night and 2 experimental nights

Secondary outcomes

  1. Analysis of sleep, diurnal somnolence, sleep latency and PRS impact on the life quality.

    Time frame: 1 test night and 2 experimental nights

  2. Hour index quantification of night respiratory events.

    Time frame: 1 test night and 2 experimental nights

  3. Hour index quantification of autonomic awakening during the sleep.

    Time frame: 1 test night and 2 experimental nights

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire de Saint Etienne

Other

Collaborators

  • Ministry of Health, France

Registry information

Official study title

Impact of Air Pollution on the Autonomic Nervous System Activity and the Presence of Sleep Apnea in Older Subjects: Longitudinal Multicentric Study

Acronym: POLLAIR

Important dates

Study start
2008
Primary completion
2010
Study completion
2010
First posted
Jan 6, 2010
Registry last updated
Jan 13, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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