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Completed

NCT Number: NCT03778489

Impact of Aerobic Exercise Training on Sympathetic Vasoconstriction and Vascular Function in Essential Hypertension

Sympathetic nervous activity plays an important role in the development of hypertension and studies have shown that the pannexin-1 channel is involved in the signalling of the sympathetic activity to the vascular bed. The main project aim is to investigate the effects of 10 weeks of high intensity training on the effect of the sympathetic nervous activity on vascular function in individuals with essential hypertension. A secondary aim is to assess the role of essential hypertension and physical activity on vascular endothelial function,

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Key information

Conditions

Hypertension,Essential Cardiovascular Diseases Essential Hypertension Hypertension Vascular Diseases

Age range

35 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Copenhagen

Copenhagen, 2100, Denmark

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Sedentary men and women age 35 - 65 years
  • Resting blood pressure >140/90 mmHg or Resting blood pressure <140/90 mmHg
  • Essential hypertension
  • Non or exclusively antihypertensive medication

Exclusion criteria

  • Hypertensive condition other than essential hypertension
  • Other chronical diseases
  • Smoking
  • Excess alcohol intake or drug abuse

Treatment and study plan

Training

Other

10 weeks of high intensity exercise training. 2-3 trainings per week of approx. 40 min.

Primary outcomes

  1. Blood pressure

    Time frame: Before and after 8 weeks of training

    Changes in systolic and diastolic blood pressure

Secondary outcomes

  1. Pannexin channel function assessed in vivo

    Time frame: Before and after 8 weeks of training

    Pannexin channel function is assessed by measurement of vascular conductance with and without channel inhibition

  2. Pannexin channel distribution in skeletal muscle tissue

    Time frame: Before and after 8 weeks of training

    Pannexin channel distribution is assessed immunohistochemically in muscle samples

  3. Sympathetic activity

    Time frame: Before and after 8 weeks of training

    Direct measurement of Muscle Sympathetic Nervous Activity via microneurography

  4. Vascular function

    Time frame: Before and after 8 weeks of training

    Vascular conductance measured by ultrasound doppler during infusion of vasoactive substances

  5. Mitochondrial function in endothelial cells

    Time frame: Before and after 8 weeks of training

    Endothelial cell mitochondrial respiration is measured by High Resolution Respirometry

  6. Reactive oxygen species formation in in endothelial cells

    Time frame: Before and after 8 weeks of training

    Endothelial cell production of reactive oxygen species is measured by High Resolution Respirometry

  7. Rheology

    Time frame: Before and after 8 weeks of training

    Platelet rheology. The viscoelastic measurements are based on attainment of the Gel Point (GP) from which the fractal dimension, df, is determined.

  8. Platelet reactivity

    Time frame: Before and after 8 weeks of training

    Platelet reactivity is assessed by multiplate aggregometry

  9. Maximal oxygen uptake

    Time frame: Before and after 8 weeks of training

    Direct Measurement of oxygen uptake during a graded test on cycle ergometer

  10. Body Composition

    Time frame: Before and after 8 weeks of training

    Measured by Dual energy x-ray absorptiometry

  11. Endothelial cell characterization

    Time frame: Before and after 8 weeks of training

    Assessment of protein and mRNA-levels of proteins of relevance for endothelial function

  12. Skeletal muscle characterization

    Time frame: Before and after 8 weeks of training

    Assessment of protein and mRNA-levels of proteins of relevance for skeletal muscle function

Sponsors and collaborators

Lead sponsor

University of Copenhagen

Other

Collaborators

  • Danish Council for Independent Research
  • Lundbeck Foundation

Registry information

Official study title

Impact of Aerobic Exercise Training on Sympathetically Mediated Vasoconstriction and Vascular Function in Individuals With Essential Hypertension (IMPROVEH)

Acronym: IMPROVEH

Important dates

Study start
2019
Primary completion
2022
Study completion
2022
First posted
Dec 19, 2018
Registry last updated
Nov 2, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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