Impact of Adapted Physical Activity on Cognitive Functions in Breast Cancer

Patient with cognitive complaint will be randomized in two groups :

• Experimental group : Immediate APA program (after randomization)
• Standard group : Delayed APA program (3 months after randomization)

APA program contains 10 sessions of APA within five weeks (twice a week). Each session is composed of 5 exercises (each made of 3 serial of 7 repetitions in slow speed).

A cognitive and quality of life assessments will occur in two groups at 3 and 6 months after randomization.

The primary objective of the study is to evaluate the impact of APA program on the improvement of cognitive functions in patients with breast cancer who have been treated by adjuvant chemotherapy.

Inclusion criteria

• Women
• More than 18 years old
• Locally advanced breast cancer
• Patient who undergone surgery
• Cognitive complaint (FACT-COG inferior or equal to 8/16)
• No metastasis at the inclusion
• Patient who received adjuvant therapy by chemotherapy
• Patient with a social protection
• Barbizet scale Superior or equal to 3
• No neurological history
• No medical contraindication to APA
• Inform consent signed

Exclusion criteria

• Metastatic breast cancer
• History of other cancer (in 5 years before inclusion)
• Current chemotherapy or radiotherapy
• Chemotherapy or radiotherapy ended for more than 6 months
• Current APA program
• Blood transfusion for less than 6 mois
• Minimal mental score inferior to normal
• Patient no able to respond to the cognitive test
• Patient no able to realize APA program
• Drug use
• Alcohol abuse
• Patient Under guardianship or curatorship or deprived of liberty