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NCT Number: NCT06664567

Impact of a Proactive Strategy of General Practitioners on CRC Screening

In this registry-based cluster randomized controlled trial, we will assess the impact of a proactive strategy of general practitioners (GP) who will systematically provide screening kits of colorectal cancer (CRC) to all patients of even age (50, 52, 54...up to 74 years) versus usual practice where the eligible population receive an invitation letter to visit the general practitioner and receive the screening kit.

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Key information

About this study

Colorectal cancer is one of the leading causes of cancer and death in France in both men and women. The generalized screening rate is about 30% in France, far from the expected 65%, despite the fact that screening is free and a letter of invitation is sent to the individual's home, and despite the financial incentives provided to the practitioner. Different studies have looked for the causes of non-implementation by the individual: negligence, "dirty"; forgetfulness, and the practitioner: organizational problem, communication problem. A few intervention studies have been carried out with little success: sending the invitation to the individual's home, sending a letter of reminder, sending a letter of general information on screening to the practitioner, sending the list of patients who have not taken the test to the practitioner allows for a few percent improvement in screening. In this registry-based cluster randomized controlled trial, we will assess the impact of a proactive strategy of general practitioners who will systematically provide screening kits of colorectal cancer to all patients of even age (50, 52, 54 years...up to 74 years) versus usual practice where the eligible population receive an invitation letter to visit the general practitioner and receive the screening kit. The screening rate will be calculated for each arm at the end of the 2-year study with data from the health insurance.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • medical practices in Aquitaine region and their visiting patients eligible for colorectal cancer screening individuals aged between 50 and 74 years at intermediate risk of colorectal cancer).

Exclusion criteria

  • medical practices with less than five individual eligible for colorectal cancer screening.
  • visiting patients aged less than 50 years or more than 74 years or at high or very high risk of colorectal cancer.

Treatment and study plan

Colorectal cancer screening test

Behavioral

delivery of colorectal cancer screening test by GP

Primary outcomes

  1. Participation rate in CRC screening

    Time frame: 2 years after the start of protocol

    The primary endpoint of this trial is the rate of participation rate in CRC screening in the eligible patient population grouped with or without intervention. This criterion will be measured by retrospective analysis of retrospective analysis of National Health Data System data.

Secondary outcomes

  1. Positive test results

    Time frame: 2 years after the start of protocol

    Rate of patients with positive test results

  2. Positive test at an early stage

    Time frame: 2 years after the start of protocol

    rate of patients tested positive at an early stage

  3. Positive test at a last stage

    Time frame: 2 years after the start of protocol

    rate of patients testing positive at a late stage

Study contacts

Contact information is provided by the study sponsor or research team.

Christele BLANC-BISSON, Dr

CONTACT

[email protected]

05 56 65 55 00 ext. +33

Pierre POULIZAC

CONTACT

[email protected]

05 57 82 08 49 ext. +33

Sponsors and collaborators

Lead sponsor

University Hospital, Bordeaux

Other

Registry information

Official study title

Impact of a Proactive Strategy of General Practitioners on CRC Screening: a Registry-based Cluster-based Randomized Controlled Trial

Acronym: DECORE

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Oct 29, 2024
Registry last updated
Sep 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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