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OpenTrials
Completed

NCT Number: NCT05344287

Impact of a Plant-Based Diet on Indices of Cardiovascular Health in African Americans

The role of diet in preventing hypertension and cardiovascular diseases in African Americans, who have a much higher risk of developing these diseases, is not well understood. Therefore, this project will investigate whether African Americans following a 100% plant-based diet have more optimal blood pressure, vascular function, and blood lipid profiles, along with lower systemic inflammation relative to African Americans following a typical American diet.

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Key information

Conditions

Cardiovascular Diseases Diet, Healthy Hypertension Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Observational

Primary location

UT Arlington - Science and Engineering Innovation and Research Building

Arlington, Texas, 76019, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Self-identify as African American/Black
  • Self-reported adherence to either a typical American diet (not following a specific diet pattern) or 100% plant-based (vegan) diet
  • Age 18-40

Exclusion criteria

  • History of smoking within 2 years or being a current smoker
  • Taking vasoactive medications
  • Having overt cardiovascular, metabolic, or neurological disease
  • Pregnant individuals

Treatment and study plan

Typical American Diet

Other

Participants self-reported adherence to a typical American diet prior to enrolling in the study. This factor determined cross-sectional group allocation.

Plant-Based Diet

Other

Participants self-reported adherence to a 100% plant-based diet prior to enrolling in the study. This factor determined cross-sectional group allocation.

Primary outcomes

  1. Lipid profile (Total-C, LDL-C, VLDL-C, HDL-C, TG)

    Time frame: Day 1

  2. C-reactive protein

    Time frame: Day 1

  3. Post-occlusive brachial artery flow-mediated dilation (% change in brachial artery diameter from resting baseline)

    Time frame: Day 1

  4. Post-occlusive forearm reactive hyperemia (% change in brachial artery blood velocity from resting baseline)

    Time frame: Day 1

  5. Pulse wave velocity (carotid-to-femoral)

    Time frame: Day 1

  6. Augmentation index (AIx@HR75)

    Time frame: Day 1

  7. Cerebral vascular reactivity (% change in cerebrovascular conductance index from resting baseline)

    Time frame: Day 2

  8. Local cutaneous thermal hyperemia (% change in cutaneous vascular conductance from resting baseline)

    Time frame: Day 2

  9. Peripheral blood pressure (systolic, diastolic, mean)

    Time frame: Day 1

  10. Central blood pressure (systolic, diastolic, mean)

    Time frame: Day 1

Sponsors and collaborators

Lead sponsor

The University of Texas at Arlington

Other

Registry information

Official study title

The Impact of a Plant-Based Diet on Indices of Cardiovascular Health in African Americans: A Cross-Sectional Study

Important dates

Study start
2019
Primary completion
2020
Study completion
2020
First posted
Apr 25, 2022
Registry last updated
May 5, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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