Impact of a Non-Drug Choice on Cocaine Reinforcement

Cocaine-use disorders continue to be a significant public health concern, yet no effective medications have been identified. The goal of this study is to establish a research platform for the development of medications for treatment of cocaine abuse and dependence. This study will incorporate self-administration procedures and a non-drug alternative reinforcer, which is hypothesized to reduce the reinforcing effects of cocaine.

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Key information

Conditions

Cocaine Dependence Chemically-Induced Disorders Cocaine-Related Disorders Mental Disorders Substance-Related Disorders

Age range

21 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Early Phase 1

Primary location

Laboratory of Human Behavioral Pharmacology

Lexington, Kentucky, 40536-0086, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Cocaine dependence, otherwise healthy

Exclusion criteria

Laboratory results outside of clinically acceptable ranges, history of or current serious physical or psychiatric disease

Treatment and study plan

Cocaine

Drug

Three active doses of cocaine will be made available for self-administration during experimental sessions.

Placebo

Drug

Placebo cocaine will be made available for self-administration during experimental sessions.

Primary outcomes

The Number of Times Cocaine Was Selected in the Presence of a Monetary Reward Alternative

Time frame: 9 choice trials per cocaine dose level with each trial separated by 30 minutes

The reinforcing effects of cocaine were determined using a modified progressive ratio procedure in which subjects made 9 choices between each available cocaine dose and one of three money alternatives.

Sponsors and collaborators

Lead sponsor

Joshua A. Lile, Ph.D.

Other

Registry information

Important dates

Study start: 2014
Primary completion: 2015
Study completion: 2015
First posted: Jul 24, 2013
Registry last updated: May 17, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed