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NCT Number: NCT07359287

Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care

Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France are prescribed and where misuse remains common.

We are proposing a cluster-randomized controlled trial to evaluate the effectiveness of a bimodal intervention combining: (1) improved communication about the circulation of respiratory viruses, and (2) strengthened collaborative practices between general practitioners and pharmacists through a multidisciplinary protocol aimed at verifying that prescribed treatment durations comply with guidelines.

The study will include six primary care practices (24 physicians), with three practices in each study arm.

The aim of this project is to assess whether the bimodal intervention can reduce the duration of antibiotic treatments for upper and lower respiratory tract infections. The first component (a "viral infection prescription" tool) focuses on reducing unnecessary treatment initiation, while the second (pharmacist-led review) aims to shorten excessive prescription durations.

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Key information

Conditions

Angina Acute Bronchiolitis Acute Bronchitis Acute Otitis Media (AOM) Acute Sinusitis Angina Pectoris Bronchial Diseases Bronchitis COPD Exacerbation (AECOPD) Cardiovascular Diseases Chest Pain Community-Acquired Infections Community-Acquired Pneumonia Community-Acquired Pneumonia (CAP) Ear Diseases Heart Diseases Infections Influenza, Human Laryngeal Diseases Laryngitis Lung Diseases Lung Diseases, Obstructive Myocardial Ischemia Nasopharyngeal Diseases Nasopharyngitis Neurologic Manifestations Nose Diseases Orthomyxoviridae Infections Otitis Otitis Media Otorhinolaryngologic Diseases Pain Pathological Conditions, Signs and Symptoms Pharyngeal Diseases Pharyngitis Pneumonia RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Rhinitis Rhinitis / Nasopharyngitis Serous or Congestive Otitis Signs and Symptoms Stomatognathic Diseases Vascular Diseases Viral Respiratory Infection (e.g., Influenza) Virus Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU CAEN Normandie

Caen, 14000, France

Location status: Recruiting

Location contact

François FOURNEL, head of project

CONTACT

[email protected]

+33231065488

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient seen in consultation for an upper or lower respiratory tract infection (Angina, Acute bronchiolitis, Acute bronchitis, COPD exacerbation (AECOPD), Laryngitis, Acute otitis media (AOM), Serous or congestive otitis, Viral respiratory infection (e.g., influenza), Community-acquired pneumonia (CAP), Rhinitis / Nasopharyngitis, Acute sinusitis)

Exclusion criteria

Patient under legal protection

Treatment and study plan

Antibiotic prescribing according to guidelines

Other

If necessary, the general practitioner prescribes antibiotics to patients consulting for an upper or lower respiratory tract infection, according to the guidelines.

Primary outcomes

Number of antibiotic treatment days prescribed for upper and lower respiratory tract infections.

Time frame: The primary outcome is measured at the time of prescription (i.e. at the baseline)

The primary outcome of the study will be the number of antibiotic treatment days prescribed for upper and lower respiratory tract infections. This outcome is a composite measure reflecting the impact of both interventions. Antibiotic duration will be assessed by running a query in the electronic medical record system of the participating primary care practices. The primary outcome will be evaluated at the baseline.

Study contacts

Contact information is provided by the study sponsor or research team.

Pascal Thibon, PH

CONTACT

[email protected]

+33231065150

Renaud Verdon, PU-PH

CONTACT

[email protected]

+33231064709

Sponsors and collaborators

Lead sponsor

University Hospital, Caen

Other

Registry information

Official study title

Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care: A Cluster-Randomized Trial

Acronym: GRASP

Important dates

Study start: 2025
Primary completion: 2026
Study completion: 2026
First posted: Jan 22, 2026
Registry last updated: Jan 22, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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