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Completed

NCT Number: NCT05231499

Immunity and Nasal Fungal Colonization

Fungal colonization causes opportunistic infection that may manifest when the host's immune status deteriorates. The purpose of this study was to determine the prevalence of fungal colonization in immunocompromised subjects compared to healthy controls.

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Key information

Conditions

Colonization, Asymptomatic Asymptomatic Diseases Asymptomatic Infections Disease Attributes Infections Pathologic Processes Pathological Conditions, Signs and Symptoms

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Otolaryngology, Taichung Veterans General Hospital

Taichang, 40705, Taiwan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Immunocompromised subjects included those who had known risk factors for fungal infection, including malignant diseases, diabetes, autoimmune disorders, renal or hepatic insufficiency, organ transplantation, or use of immunosuppressants
  • Healthy volunteers had neither sinonasal symptoms nor nasal endoscopic inflammation.

Exclusion criteria

  • Patients were excluded if they were under 20 years old, were receiving antifungal medication, or were pregnant.

Treatment and study plan

nasal irrigation

Other

regular saline nasal rinse

Primary outcomes

  1. nasal lavage pooled fungal microbiota

    Time frame: 1 month

Secondary outcomes

  1. nasal lavage aspergillus qPCR

    Time frame: 1 month

Sponsors and collaborators

Lead sponsor

Taichung Veterans General Hospital

Other

Registry information

Official study title

Host Immunity and Nasal Fungal Colonization

Important dates

Study start
2018
Primary completion
2020
Study completion
2020
First posted
Feb 9, 2022
Registry last updated
Feb 9, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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