Immune Response to Influenza Vaccination

The purpose of this study is to evaluate the immune response to a routine influenza vaccination. Influenza vaccination is given as part of routine standard of care in these individuals and is not part of the study protocol. The study will evaluate for a change in response to common antigens over time after influenza vaccination to determine if changes are related to the development of chronic rejection after solid-organ transplantation. We hypothesize that the influenza vaccine contributes to the alloreactivity of T cells verses common HLA types in the donor pool.

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Key information

Conditions

Solid Organ Transplantation Chronic Disease Chronic Kidney Disease Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Infections Influenza, Human Kidney Diseases Male Urogenital Diseases Orthomyxoviridae Infections Pathologic Processes Pathological Conditions, Signs and Symptoms RNA Virus Infections Renal Insufficiency Renal Insufficiency, Chronic Respiratory Tract Diseases Respiratory Tract Infections Urogenital Diseases Urologic Diseases Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Transplant recipients (lung or kidney) 18 years or older, more than 3 months after transplantation
Transplant candidates (kidney) 18 years or older, to recieve influenza vaccination
Healthy volunteers to receive influenza vaccination

Exclusion criteria

Under 18 years of age
Pregnant
Medical contraindication for vaccine
Transplant recipients receiving acute rejection therapy within one month
Healthy volunteers with autoimmune disease or medications to mediate immune function
Receipt of live, attenuated influenza vaccine, instead of injectable vaccine

Sponsors and collaborators

Lead sponsor

The Cleveland Clinic

Other

Collaborators

University Hospitals Cleveland Medical Center

Registry information

Important dates

Study start: 2006
Primary completion: 2008
Study completion: 2008
First posted: Oct 31, 2007
Registry last updated: Oct 24, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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