Immune Response of Patients With Chronic, Staphylococcus Aureus-infected Wounds

Secondary objectives include:

• To propose a diagnostic marker of bacteraemia based on the detection of anti-S. aureus by xMAP technology
• To evaluate the kinetics of the humoral immune response to S. aureus in patients with bacteraemia
• To evaluate the virulence of S. aureus isolated from chronic, infected wounds
• To enrich the Nîmes University Hospital biobank
• To evaluate the prevalence of different antibodies within each group

Inclusion criteria

• The patient must have given his/her informed and signed consent
• The patient must be insured or beneficiary of a health insurance plan
• The patient is available for 6 months of follow up
• Patients consulting at the departments of Diabetology, Dermatology or Infectious Diseases of the participating hospitals
• inaugural or recurrent diabetic foot/ankle ulcers of Grade 2-4, or (2) who have an infected leg ulcer (arterial, venous, or mixed.

Controls:

• Absence of bacteriemia

Cases:

• Presence of bacteriemia

Exclusion criteria

• The patient is participating in another study
• The patient is in an exclusion period determined by a previous study
• The patient is under judicial protection, under tutorship or curatorship
• The patient refuses to sign the consent
• It is impossible to correctly inform the patient
• The patient is pregnant, parturient, or breastfeeding
• The patient does not have a chronic wound
• Patient with grand 1 ulcer
• Patient's wound/ulcer is not infected
• Patient's would/ulcer is infected, but not involving S. aureus