Immune Response in the SAPHO Syndrome

The aetiology of SAPHO syndrome seems to involve genetic, infectious and immunological components. The investigators examined innate and adaptative immune responses in SAPHO syndrome as compared with psoriatic arthritis and rheumatoid arthritis.

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Key information

Conditions

SAPHO Syndrome Acquired Hyperostosis Syndrome Bone Diseases Bone Diseases, Developmental Musculoskeletal Diseases Osteochondrodysplasias

Age range

1 year–70 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinical diagnosis of SAPHO syndrome
Must have bone lesions

Exclusion criteria

Infliximab treatment

Treatment and study plan

Primary outcomes

IL-8 production by PMN

Time frame: 24 h

Secondary outcomes

TNFalpha production by PMN

Time frame: 24 h

Sponsors and collaborators

Lead sponsor

Assistance Publique - Hôpitaux de Paris

Other

Registry information

Official study title

Immune Mechanisms During SAPHO Syndrome and Treatment by Etarnecept

Important dates

Study start: 2005
Study completion: 2008
First posted: Sep 19, 2012
Registry last updated: Sep 19, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed