Immune Modulation From Trichuris Suis | Clinical Trial

Key information

Conditions

Crohn Disease Colitis Colitis, Ulcerative Colonic Diseases Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Inflammatory Bowel Diseases Intestinal Diseases Intestinal Helminthiasis Ulcerative Colitis

Age range

18 year–70 year

Sex eligibility

Male

Study type

Observational

About this study

The present study investigates the effects of Trichuris suis on human mucosal and systemic immunity in a single self-infected individual.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

The included volunteer is a researcher within parasitology with main focus on Trichuris trichiura and Trichiura suis. He planned to infect himself and contacted our department with the purpose of being monitored during this infection for safety (medical supervision) and research reasons. The only clinical criterion for his inclusion in the study was that he was healthy.

Exclusion criteria

-

Treatment and study plan

Trichuris suis eggs

Biological

Live eggs from swine whipworm, Trichuris suis

Primary outcomes

Faecal egg excretion

Time frame: 15 weeks

Weekly monitoring of fecal egg counts by microscopy

Secondary outcomes

Mucosal T cell associated cytokines

Time frame: 15 weeks

Biopsy sampling during established infection
Systemic immune parameters (eosinophilia, Subtypes of circulating T cells)

Time frame: 15 weeks

Blood samples every week
Adverse events

Time frame: 15 weeks

Clinical evaluation every week

Sponsors and collaborators

Lead sponsor

University of Aarhus

Other

Registry information

Official study title

Mucosal and Systemic Immune Modulation From Trichuris Suis in a Self-infected Individual

Important dates

Study start: 2012
Primary completion: 2012
Study completion: 2012
First posted: Mar 14, 2017
Registry last updated: Mar 14, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed