Immune Correlates of Cardiac Structure and Function

Inclusion criteria

• Individuals 20-45 years of age
• Willingness and ability to provide signed and dated written informed consent, prior to any study-related procedures
• Diagnosed with HIV <10 years of age or physician confirmation of perinatal HIV infection
• On antiretroviral treatment (ART) for at least the last greater than or equal to 6 months
• Willingness to undergo Cardiovascular magnetic resonance imaging (CMR)
• Willingness to undergo echocardiogram (ECHO) (may be included if ECHO has been done at Duke in the previous 24 months).
• Willingness to have research blood draw

Exclusion criteria

• Contraindication to CMR (metal fragments in eyes or face, implanted electronic devices such as pacemakers, defibrillators, cochlear implants, or nerve stimulators, aneurysm clips)
• Estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73m2
• History of anaphylactic reaction to gadolinium contrast
• Inability to complete an MRI scan in the past due to anxiety
• Recent acute medical illness resulting in recent hospitalization (in past 90 days)
• History of: Coronary artery disease (CAD), Myocardial infarction (MI), moderate-severe valvular disease, congenital heart disease, heart failure, non-ischemic CM, Atrial fibrillation/flutter, implantable cardioverter defibrillator (ICD)/pacemaker, myocarditis prior
• Current Symptoms of Shortness of breath, severe chest pain, palpations, difficulty breathing on exertion, swelling of legs
• Known to be pregnant or current breastfeeding
• Known to be on hemodialysis
• Inability to breath hold for 5-10 seconds
• Known to have an ejection fraction <45% in the past 24 months
• Active cancer or cancer chemotherapy or radiation treatment in the prior year.
• Comorbid inflammatory disease, specifically treated for rheumatoid arthritis (RA) or lupus (SLE)
• Chronic use of steroids or anti-inflammatory therapy