Immune Benefits of WGP in Elderly

Inclusion criteria

• Male and female elderly volunteers equal or above age of 70
• Pre-frail and frail subjects (based on Fried's criteria)
• Willing to be vaccinated against influenza and having no contraindication to receive influenza vaccination
• Having obtained his/her (or his/her legal representative's) informed consent

Exclusion criteria

• Subject with a rapidly deteriorating health status (terminal, severe, or uncontrolled acute/chronic diseases)
• Allergy to eggs or influenza vaccine components.
• Subject who has received any vaccination in the last 3 months or has previously been vaccinated with the current seasonal influenza vaccine.
• Subject who is currently taking, or has taken in the last 4 weeks, or will take immune modulating medication during the study, including steroid, immune suppressive treatment.
• Subject who has taken antibiotics in the last 2 months prior to entering the study.
• Subject who is consuming regularly prebiotic and/or probiotic supplements, yogurts, and/or other dietary supplements.
• Personal or family history of Guillain-Barre syndrome
• BMI>35 kg/m2
• Subject who has received blood transfusion or had a blood donation during the last 4 weeks prior to the beginning of this study.
• Subject who cannot be expected to comply with the study procedures
• Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study