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NCT Number: NCT06229262

Immune and Cognitive Benefits of Mango Intake in Young Adults

The main objectives of our proposed study are to determine the effects of mango consumption on immune and cognitive functions in free-living college going young adults aged 18-30 years

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Key information

Conditions

Cognition Immunity

Age range

18 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Loma Linda University School of Public Health

Loma Linda, California, 92350, United States

About this study

The main objectives of our proposed study are to determine the effects of mango consumption on immune and cognitive functions in free-living college going young adults aged 18-30. To accomplish these objectives, a randomized controlled, parallel design study is proposed with two groups consuming their habitual diet, but with one (Mango group) receiving 1.5 servings of mango/day and the other (Control group) abstaining from eating any mango for the duration of the study.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male and female college students aged 18-30 years

Exclusion criteria

  • known intolerance or allergy to mangos
  • regular intake of mangos and/or fruits of a similar nutritional content such as peach, nectarine, papaya, apricot and cantaloupe
  • using cognition and/or immune-boosting supplements or vitamins
  • recent exposure to antibiotics and corticoids
  • uncontrolled chronic diseases and mental illnesses, clinical depression, and immunocompromised state

Treatment and study plan

Mango group

Dietary Supplement

Participants will consume 1.5 cups of mangos per day for 12 weeks.

Primary outcomes

  1. Changes in lymphocyte populations

    Time frame: baseline to 12 weeks

    Immunophenotyping will be performed by flow cytometry to measure the number of T helper, T cytotoxic, Naive and memory cells and B cells

  2. Changes in Lymphocyte activity

    Time frame: baseline to 12 weeks

    The production of lymphocytes will be measured in the supernatant using enzyme linked immunosorbent assay (ELISA)

  3. Changes in cytokine production

    Time frame: baseline to 12 weeks

    The cytokines produced due to lymphocyte activity will be measured in the supernatant using enzyme linked immunosorbent assay (ELISA)

  4. Changes in serum inflammatory cytokine concentration

    Time frame: baseline to 12 weeks

    changes in the concentrations of the inflammatory cytokines will be performed on serum using enzyme linked immunoassay (ELISA) will include hs-CRP, interleukin (IL)-1B, IL-6, TNF a, IL-10, IL-2, IFN-γ, E-selectin,

  5. changes from baseline in global cognitive composite score

    Time frame: baseline to 12 weeks

    The composite score will be calculated using the scores from the tests listed below. Scores will be calculated with the standardized scores of each test as the score of each participant minus the group mean and divide by its standard deviation. The composite score is the mean of the standardized scores. the 5 tests are: Rey Auditory Verbal Learning Test (RAVLT), Brief Visuospatial Memory Test, Digit Span, FAS Word Fluency, Symbol Digit Modalities Test

  6. Change in serum brain-derived neurotrophic factor (pg/mL)

    Time frame: baseline to 12 weeks

    changes in serum brain-derived neurotrophic factor (pg/mL) assessed by ELISA

Study contacts

Contact information is provided by the study sponsor or research team.

Amandeep Wright, MPH

CONTACT

[email protected]

909-558-4300 ext. 47169

Sujatha Rajaram, PhD

CONTACT

[email protected]

909-558-4300 ext. 47228

Sponsors and collaborators

Lead sponsor

Loma Linda University

Other

Collaborators

  • National Mango Board

Registry information

Official study title

Immune and Cognitive Benefits of Mango Intake in Young Adults: A Randomized Trial

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jan 29, 2024
Registry last updated
Jul 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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