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NCT Number: NCT07460076

Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone

Immediate implant placement in the esthetic zone is often associated with buccal bone deficiency, which may compromise esthetic outcomes and long-term implant stability. Autogenous bone graft harvested from the maxillary tuberosity provides corticocancellous bone with favorable biological properties and may help reconstruct the buccal bone plate during immediate implant placement.

This prospective case series aims to evaluate the clinical and esthetic outcomes of immediate implant placement combined with autogenous maxillary tuberosity graft in the esthetic zone. The primary outcomes include buccal bone thickness measured on cone-beam computed tomography (CBCT), facial soft tissue thickness measured clinically, and the pink esthetic score (PES) after implant restoration.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Medicine and Pharmacy at Ho Chi Minh City

Ho Chi Minh City, Ho Chi Minh, 700000, Vietnam

Location status: Recruiting

Location contact

Duy Anh Tran, DDS

CONTACT

[email protected]

+84 868324216

About this study

Immediate implant placement has become a widely accepted treatment modality in the esthetic zone. However, the presence of buccal bone defects following tooth extraction may negatively affect peri-implant tissue stability and esthetic outcomes. Autogenous bone graft harvested from the maxillary tuberosity has been proposed as a reliable grafting material due to its corticocancellous structure and high osteogenic potential.

This prospective interventional case series aims to evaluate the effectiveness of autogenous maxillary tuberosity graft used in conjunction with immediate implant placement in the esthetic zone. Patients requiring extraction and implant placement in the maxillary esthetic region will be treated with immediate implant placement and augmentation using a two-layer autogenous graft harvested from the maxillary tuberosity, consisting of cortical bone and connective tissue.

Clinical and radiographic outcomes will be assessed during follow-up. Buccal bone thickness will be evaluated using cone-beam computed tomography (CBCT). Facial soft tissue thickness will be measured clinically. Esthetic outcomes will be assessed using the pink esthetic score (PES) following definitive prosthetic restoration.

The results of this study are expected to provide clinical evidence regarding the effectiveness of maxillary tuberosity autogenous grafts for improving peri-implant tissue stability and esthetic outcomes in immediate implant placement.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 years or older
  • Patients requiring single implant placement in the maxillary esthetic zone
  • Indication for immediate implant placement following tooth extraction
  • Presence of a buccal bone defect requiring augmentation with an autogenous maxillary tuberosity bone graft
  • Adequate oral hygiene and ability to maintain postoperative care
  • Willingness to participate in the study and provide informed consent

Exclusion criteria

  • Uncontrolled sHistory of radiotherapy in the head and neck region ystemic diseases
  • History of radiotherapy in the head and neck region
  • Active periodontal disease or untreated oral infection
  • Heavy smoking (more than 10 cigarettes per day)
  • Pregnancy or lactation
  • Severe parafunctional habits
  • Insufficient bone volume preventing implant placement with the planned protocol
  • Patients unable to attend follow-up visits

Treatment and study plan

Immediate Implant Placement With Maxillary Tuberosity Autogenous Graft

Procedure

Immediate implant placement in the maxillary esthetic zone combined with autogenous bone graft harvested from the maxillary tuberosity. The graft is used to reconstruct the buccal bone plate and improve peri-implant tissue stability and esthetic outcomes.

Primary outcomes

  1. Buccal Bone Thickness

    Time frame: 6 months after implant placement

    Buccal bone thickness around the implant measured on cone-beam computed tomography (CBCT) in the mid-facial aspect of the implant site.

Secondary outcomes

  1. Facial Soft Tissue Thickness

    Time frame: 6 months after implant placement

    Facial peri-implant soft tissue thickness measured clinically at the mid-facial aspect of the implant site.

Other outcomes

  1. Pink Esthetic Score (PES)

    Time frame: 6 months after implant placement

    Esthetic evaluation of peri-implant soft tissue using the Pink Esthetic Score (PES) assessed after prosthetic restoration.

Study contacts

Contact information is provided by the study sponsor or research team.

Duy Anh Tran, DDS

CONTACT

[email protected]

+84 868324216

Sponsors and collaborators

Lead sponsor

University of Medicine and Pharmacy at Ho Chi Minh City

Other

Registry information

Official study title

Clinical and Esthetic Outcomes of Immediate Implant Placement With Autogenous Maxillary Tuberosity Graft in the Esthetic Zone: A Prospective Case Series

Acronym: TUBERO-IMPLANT

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Mar 10, 2026
Registry last updated
Mar 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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