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Completed

NCT Number: NCT06632119

Immediate Effects of High-intensity Laser Therapy on Knee Joint Position Sense and Knee Muscle Strength in Patients with Knee Osteoarthritis

The goal of this clinical trial is to compare whether HILT versus Sham-HILT is effective to reduce pain, improve knee joint position sense, and knee muscle strength.

Participants will undergo a single-session of HILT or Sham-HILT, the measurements of pain, knee joint position sense error, and knee muscle strength will be done at before, immediately after, and 24-hour after the single-session intervention.

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Key information

Conditions

Knee Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Neurologic Manifestations Osteoarthritis Osteoarthritis, Knee Pain Pathological Conditions, Signs and Symptoms Rheumatic Diseases Signs and Symptoms

Age range

50 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Physical Therapy

Salaya, Changwat Nakhon Pathom, 73170, Thailand

About this study

The investigators would like to investigate whether single session of high-intensity laser therapy (HILT) is promising to see the changes in individuals with knee osteoarthritis (KOA)-related knee pain regarding pain intensity, knee joint position sense, and knee muscle strength.

The objectives of this study is to compare pre and post, and between the two groups (HILT versus Sham-HILT) at after interventions regarding pain, knee joint position sense, and knee muscle strength.

Participants will undergo a single-session of HILT or Sham-HILT by an experienced musculoskeletal physical therapist, the measurements of pain, knee joint position sense error, and knee muscle strength will be done at before, immediately after, and 24-hour after the single-session intervention.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • knee pain greater than 3 on the Visual Analog Scale (VAS) for more than 3 months
  • diagnosed with unilateral knee osteoarthritis by a physician or meeting the American College of Rheumatology Classification Criteria for clinical knee osteoarthritis
  • the severity of knee osteoarthritis is classified as grades 0-3 according to the Kellgren-Lawrence (KL) classification
  • should not have undergone any specific treatments in the 3 months preceding the recruitment for the study, such as steroid injections.

Exclusion criteria

  • any other musculoskeletal problems associated with knee pain
  • musculoskeletal problems associated with the hip and ankle joints
  • a history of lower limb fracture
  • neurological conditions
  • contraindications for laser therapy

Treatment and study plan

High-intensity laser therapy

Device

high-intensity laser therapy (HILT) machine, ASA laser

Sham-HILT

Device

Sham-HILT, HILT machine without laser release

Primary outcomes

  1. Knee joint position sense

    Time frame: Baseline, immediately after, 24-hour after intervention

    Knee joint position sense, the investigators used the joint position repositioning technique. The participants were measured for joint position reposition technique with a smartphone application "Measure App" (iPhone 12 Pro Max, Apple Inc., USA). The smartphone attached at shank of tibia bone at the malleolar level. The participants sat in the starting position knee flexion 90°. Then the participants with eyes closed were actively guided to the knee flexion 45 degrees and hold for 3 seconds. The data was recorded the difference between performed position and targeted position.

Secondary outcomes

  1. Knee muscle strength

    Time frame: Baseline, immediately after, 24-hour after intervention

    The muscle strength measured both quadriceps and hamstring muscles by the handheld dynamometer at 90°.

  2. Pain

    Time frame: Baseline, immediately after, 24-hour after intervention

    The participants rated the pain scores using a 10-cm visual analog scale (VAS) ranged from 0 "no pain at all" on the left end to 10 "worst pain imaginable" on the right end.

Sponsors and collaborators

Lead sponsor

Mahidol University

Other

Registry information

Acronym: HILT on KOA

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Oct 8, 2024
Registry last updated
Oct 9, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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