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NCT Number: NCT05238623

Imbalances of Regional Pulmonary Ventilation in Patients With Post-acute-COVID-19

Investigation of the correlation of CT-morphological changes of the lung compared to regional ventilation distribution on electrical impedance tomography in patients with post-acute-Covid-19 symptoms.

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Key information

Conditions

COVID-19 Pneumonia COVID-19 Chronic Disease Coronaviridae Infections Coronavirus Infections Disease Attributes Electric Impedance Infections Lung Diseases Nidovirales Infections Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Pneumonia, Viral Post-Acute COVID-19 Syndrome Post-Infectious Disorders RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Klinik für Notfallmedizin

Jena, Thuringia, 07747, Germany

About this study

Prospective non-interventional, monocentric observational study on imbalances in regional lung ventilation compared to chest CT in post-acute-Covid-19. The aim is to verify the agreement between computerized tomography derived imaging variables and electrical impedance tomography in detecting lung ventilation imbalances. The primary study objective is to match CT morphological changes in regional ventilation in post-acute-COVID-19 patients and/or changes in lung function examination, with changes that can be visualized by electroimpedance tomography.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • all patients undergoing a Chest CT due to suspected post-acute-Covid-19-syndrome
  • >18 years
  • informed consent.

Exclusion criteria

  • trauma patients and patients with unstable spinal injuries or fractures
  • patients with an BMI over 50
  • patients with uncontrolled body movements
  • Patients with a pacemaker

Treatment and study plan

additional EIT Measurement

Diagnostic Test

Patients who receive standard CT and pulmonary function testing also receive electroimpedance tomography measurement. The lunghealthy Patients in the control group only receive a EIT.

Primary outcomes

  1. Correlation between tomography and electroimpedance tomography

    Time frame: until May 2022

    The primary study objective is to match CT morphological changes in regional ventilation in post-COVID patients and/or changes in lung function examination with changes that can be visualized by electroimpedance tomography.

Secondary outcomes

  1. Correlation between lung function testing and electroimpedance tomography

    Time frame: until May 2022

Study contacts

Contact information is provided by the study sponsor or research team.

Jan-Christoph Lewejohann, Dr.

CONTACT

[email protected]

+49 3641 9 32 20 13

Phillip A. Reuken, Dr.

CONTACT

[email protected]

+49 3641 9 32 4504

Sponsors and collaborators

Lead sponsor

Jan-Christoph Lewejohann

Other

Registry information

Official study title

Imbalances of Regional Pulmonary Ventilation in Patients With Post-acute-COVID-19 Symptoms

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Feb 14, 2022
Registry last updated
Sep 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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