Imaging the Colon Using a Colonoscope Compatible Imaging Probe

The goal of this study is to use a colonoscope compatible device capable of taking images of the lower gastrointestinal tract. The main question it aims to answer is:

Is the colonoscope compatible optical coherence tomography probe (CC-OCT probe) an effective device to use to take images of the gut?

During the participant's standard of care colonoscopy, the CC-OCT probe will be inserted into the colonoscope. The CC-OCT probe will then collect images of the participant's gastrointestinal tract in real time.

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Key information

Conditions

Colon Polyps Colonic Polyps Colonoscopy Intestinal Polyps Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Polyps

Age range

45 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

45 years of age or older
Capable of giving informed consent
Capable of following bowel prep instructions

Exclusion criteria

75 years of age or older
Any contraindication to bowel prep or colonoscopy
Current diagnosis of any bleeding disorders
Currently using drugs that interfere with coagulation (excluding low-dose aspirin)
Pregnancy

Treatment and study plan

Feasibility of using a CC-OCT probe to image the GI tract

Device

250 participants will be enrolled in this study. All consented participants will receive the same intervention.

Primary outcomes

Ability of the CC-OCT to image the lower GI tract

Time frame: Images are collected during the study procedure and analyzed within one year of collection

Sponsors and collaborators

Lead sponsor

Massachusetts General Hospital

Other

Collaborators

National Institutes of Health (NIH)

Registry information

Official study title

Study for Imaging the Lower Gastrointestinal Tract Using a Colonoscopy-Compatible OCT Probe

Important dates

Study start: 2026
Primary completion: 2028
Study completion: 2029
First posted: Jan 26, 2026
Registry last updated: Jul 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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