Imaging Response to Immunotherapy and Radiation Therapy in Patients With Liver Metastases

Patients will be imaged with MRE at the time of the RT planning MRI, prior to the induction of RT and immunotherapy. Research imaging will be in addition to standard imaging studies performed at time points consistent with the standard of care (at the time of the RT planning MRI and the first clinical follow-up). An additional MRE exam will be performed at the end of treatment outside the standard of care imaging.

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Key information

Conditions

Liver Metastases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic

Rochester, Minnesota, 55905, United States

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age ≥ 18 years
Diagnosis of solid cancers with the presence of one or more liver metastases
Minimum metastasis diameter ≥ 2 cm
Planning to receive radiation therapy with immunotherapy
Willingness to participate in mandatory imaging studies at Mayo Clinic Rochester

Exclusion criteria

Contraindications for MRI including claustrophobia, pace maker, metal implants, aneurism clips
Patients who are not able to consent

Treatment and study plan

Magnetic Resonance Elastography

Other

rapidly developing technology for quantitatively assessing the mechanical properties of tissue, using externally applied mechanical waves

Other names: MRE

Primary outcomes

Quantify tissue mechanical properties of the liver and liver tumor using MRE in patients receiving radiation therapy + immunotherapy at baseline, mid-treatment and time of followup imaging determined by standard of care to assess response to therapy

Time frame: 1 year

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Important dates

Study start: 2018
Primary completion: 2019
Study completion: 2019
First posted: Jan 17, 2018
Registry last updated: Jul 9, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed