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OpenTrials
Completed

NCT Number: NCT03570398

Imaging Possible Appendicitis With CT

Pain in the right lower abdomen is one of the commonest reasons patients present to general surgeons as an emergency. Whether or not such patients have appendicitis is crucial to their assessment. In UK practice, when the diagnosis is unclear, ultrasound scanning (US) is commonly used to investigate the problem. US is very safe but it will only visualise the appendix in the minority of cases. As a result, the sensitivity for diagnosing appendicitis in this setting is probably only 5-30%. Alternatively, computed tomography (CT) is an accurate way of diagnosing appendicitis in over 90% of cases. CT scans are readily available and with modern scanners, high quality images can be achieved with lower radiation doses. Unenhanced scanning avoids the use of contrast media and permits further reductions in ionising radiation exposure.

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Key information

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

South Tees Hospitals NHS Foundation Trust

Middlesbrough, TS4 3BW, United Kingdom

About this study

Pain in the right lower abdomen is one of the commonest reasons patients present to general surgeons as an emergency. Whether or not such patients have appendicitis is crucial to their assessment. In UK practice, when the diagnosis is unclear, ultrasound scanning (US) is commonly used to investigate the problem. US is very safe but it will only visualise the appendix in the minority of cases. As a result, the sensitivity for diagnosing appendicitis in this setting is probably only 5-30%. Alternatively, computed tomography (CT) is an accurate way of diagnosing appendicitis in over 90% of cases. CT scans are readily available and with modern scanners, high quality images can be achieved with lower radiation doses. Unenhanced scanning avoids the use of contrast media and permits further reductions in ionising radiation exposure.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Acute presentation with abdominal pain and/or tenderness which is most marked in the right lower abdomen

Exclusion criteria

  • Age<18
  • Age>60
  • Pregnancy
  • Patients with a firm clinical diagnosis of appendicitis where surgical management is indicated at presentation
  • Patients who have undergone CT scanning within the past two months
  • Patients with cognitive impairment who would lack capacity to give consent
  • Inability to understand written or spoken English
  • Patients who have previously undergone appendicectomy

Treatment and study plan

unenhanced abdomino-pelvic CT scan

Other

unenhanced abdomino-pelvic CT scan

Abdominal ultrasound

Other

abdominal ultrasound

Primary outcomes

  1. Feasibility

    Time frame: 2 years

    As assessed by the rate of refusal to participate amongst eligible patients

Sponsors and collaborators

Lead sponsor

South Tees Hospitals NHS Foundation Trust

Other

Registry information

Official study title

A Feasibility Randomised Control Trial to Evaluate the Role of Computed Tomography in Patients With Indeterminate Right Iliac Fossa Pain

Acronym: IMPACT

Important dates

Study start
2016
Primary completion
2018
Study completion
2018
First posted
Jun 27, 2018
Registry last updated
Jun 27, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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