Skip to main content
OpenTrials
Completed

NCT Number: NCT01889693

Imaging of Atherosclerosis With 68Ga-MSA

Despite of intensive efforts, no specific ath¬erosclerosis-targeting agent labeled with positron emitter is not yet available. Fortunately, some scientists made the major advance in the field of clinical atherosclerosis molecular imaging by the metabolic PET reporter agent 18F(fluorine-18)-FDG(Fludeoxyglucose) applied to noninvasively image plaque macrophages in carotid arteries. However, coronary and cerebral arterial segments remain uninterpretable due to metabolic property of 18F-FDG. Applying the character of the terminal mannose residues of MSA binding with the mannose receptors of macrophages in atherosclerosis, we investigate whether 68Ga-MSA can be a novel agent for non-invasive molecular imaging of atherosclerotic lesion in PET.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Atherosclerosis Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Noninvasive Imaging of Atherosclerosis Vascular Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Korea University Guro Hospital

Seoul, 152-703, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • acute coronary syndrome(acute myocardial infarction, unstable angina)
  • chronic stable angina
  • control without coronary artery disease

Exclusion criteria

  • pregnancy, allergy to albumin, chronic inflammatory disease

Treatment and study plan

Primary outcomes

  1. comparison of SUV(standard uptake unit) at atherosclerotic plaque of aorta and carotid arteries among 3 groups

    Time frame: 1 day at the time of PET(positron emission tomogram) imaging

Secondary outcomes

  1. side effect of PET imaging with 68Ga-MSA

    Time frame: with 7 days after PET imaging

    any side effects including changes of biochemical values and vital signs

Sponsors and collaborators

Lead sponsor

Korea University

Other

Collaborators

  • Ministry of Health & Welfare, Korea

Registry information

Official study title

Identification of Vascular Inflammatory Image Using a 68Ga-MSA(Gallium-68 Neomannosyl Human Serum Albumin) in Patients With Atherosclerotic Lesions

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Jun 28, 2013
Registry last updated
Aug 27, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.