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Completed

NCT Number: NCT03232723

Imaging Non-brain Electromagnetic Activity in Healthy Adults Using MEG

The primary purpose of this study is to determine the effectiveness of the Magnetoencephalography (MEG) instrument to record electrical activity from parts of the body other than the brain. This study will examine if electrical activity from parts of the body, other than the brain, can be imaged by the MEG instrument. Finding will contribute to studies of pain, since abnormal electrical activity in skeletal muscle is the basis of pain, which can be severe, yet there is no non-invasive way to image this abnormal activity. This is particularly relevant to deep muscle pain and back pain.

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Key information

Conditions

Chronic Pain Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

New York University School of Medicine

New York, 10016, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy adults who are willing and able to provide informed consent.

Exclusion criteria

  • Subjects with characteristics incompatible with MEG recordings as listed on the MEG Safety checklist (Appendix A),
  • Involuntary, uncontrolled tremor,
  • chronic pain.
  • pregnant women (based on self-report).

Treatment and study plan

Whole-cortex MEG System (with optional EEG)

Diagnostic Test

"Whole-Cortex MEG System" non- invasively measures the magnetoencephalographic (MEG) signals (and, optionally, electroencephalographic EEG signals) produced by electrically active tissue of the brain. These signals are recorded by a computerized data acquisition system, displayed, and may then be interpreted by trained physicians to help localize these active areas. The location may then be correlated with anatomical information of the brain. MEG is routinely used to identify the locations of visual, auditory, somatosensory, and motor cortex in the brain.

Primary outcomes

  1. Determination of optimal position to obtain safe and effective imaging of structures other than the brain.

    Time frame: 2 Weeks

    • Hand position 1 relaxed
    • Hand position 1 muscles active
    • Hand position 2 relaxed
    • Hand position 2 muscles active
    • Neck and Jaw, relaxed
    • Neck and Jaw, tensed
    • Upper torso relaxed
    • Area of interest 1 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)
    • Area of interest 1 tensed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)
    • Area of interest 2 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)
    • Area of interest 2 tensed (areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)

  2. Evoked activity to obtain safe and effective imaging of structures other than the brain

    Time frame: 2 Weeks

    • Hand position 1 relaxed
    • Hand position 1 muscles active
    • Hand position 2 relaxed
    • Hand position 2 muscles active
    • Neck and Jaw, relaxed
    • Neck and Jaw, tensed
    • Upper torso relaxed
    • Area of interest 1 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)
    • Area of interest 1 tensed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)
    • Area of interest 2 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)
    • Area of interest 2 tensed (areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)

Secondary outcomes

  1. Dominant frequency of non-brain electrical activity in healthy adults.

    Time frame: 2 Weeks

    • Hand position 1 relaxed
    • Hand position 1 muscles active
    • Hand position 2 relaxed
    • Hand position 2 muscles active
    • Neck and Jaw, relaxed
    • Neck and Jaw, tensed
    • Upper torso relaxed
    • Area of interest 1 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)
    • Area of interest 1 tensed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)
    • Area of interest 2 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)
    • Area of interest 2 tensed (areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)

  2. Location of non-brain of activity in healthy adults.

    Time frame: 2 Weeks

    • Hand position 1 relaxed
    • Hand position 1 muscles active
    • Hand position 2 relaxed
    • Hand position 2 muscles active
    • Neck and Jaw, relaxed
    • Neck and Jaw, tensed
    • Upper torso relaxed
    • Area of interest 1 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)
    • Area of interest 1 tensed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)
    • Area of interest 2 relaxed(areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)
    • Area of interest 2 tensed (areas are not specific for Runs 9-11. (Possible areas are groups of muscles in the back and limbs.)

Sponsors and collaborators

Lead sponsor

NYU Langone Health

Other

Registry information

Acronym: BODMEG

Important dates

Study start
2017
Primary completion
2017
Study completion
2017
First posted
Jul 28, 2017
Registry last updated
Jun 5, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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