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Completed

NCT Number: NCT04908306

IMAGE-HF: Project IIa Canadian CArdiomyopathy Registry for Device Therapy

Delayed enhanced MRI in patients (of either ischemic or non-ischemic cause) being referred for primary prevention ICD

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Key information

Sex eligibility

All sexes

Study type

Observational

About this study

Device therapy using defibrillators and cardiac resynchronization therapy (CRT) is an important advance in the care of patients with acquired heart disease and heart failure. In specific groups these devices appear to significantly reduce the risk of sudden cardiac death and progression of heart failure. However, our ability to identify ideal candidates, and those who are most likely to respond and benefit from this therapy, is poor.

Preliminary studies using specialized Magnetic Resonance Imaging (MRI) appears to be one of the more valuable ways of predicting response to device therapy and holds substantial promise for patients with cardiomyopathy.

Large, prospective registries are necessary to explore its real-world utility for risk prediction across a broad spectrum of patients. Can-CARD MR is a national, multi-centre registry designed to address this particular need.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • .Any patient accepted for primary prevention ICD (+/-) CRT)

Exclusion criteria

  • Known contra-indications to MRI.
  • Recent myocardial infarction or revascularization procedure within the past 3 months.
  • GFR (glomerular filtration rate) ≤ 30 ml. / min/ m2.

Treatment and study plan

Primary outcomes

  1. Occurrence of a)appropriate ICD therapy (shock or anti-tachycardia pacing (ATP)) or sudden cardiac death

    Time frame: 1 year

    Occurrence of a)appropriate ICD therapy (shock or anti-tachycardia pacing (ATP)) or sudden cardiac death

Sponsors and collaborators

Lead sponsor

Ottawa Heart Institute Research Corporation

Other

Registry information

Official study title

IMAGE-HF: Project IIa - Canadian CArdiomyopathy Registry for Device Therapy (CanCARD-MR)

Acronym: CanCARD-MR

Important dates

Study start
2011
Primary completion
2024
Study completion
2024
First posted
Jun 1, 2021
Registry last updated
May 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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