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NCT Number: NCT07475793

Image Guided Genicular Nerve Radiofrequency Ablation for Chronic Knee Osteoarthritis

The goal of this prospective randomized control trial is to provide continued pain relief, classically long-lasting 3 to12 months, and enhanced function in patients following: both gender; male and female, age group; >50yr, healthy volunteers along with Radiographic diagnosis of knee OA with KL grade 3 and 4 in addition of Chronic knee pain ≥ 6 months and patients with ≥50% decrease in pain strength after diagnostic genicular nerve block. The main question it aims to answer is:

Is ultrasound-guided genicular nerve RFA more efficient in lowering pain intensity at six months contrasted with fluoroscopic guided method in patients with chronic knee osteoarthritis? Researchers will compare Group A (Fluoroscopic) to Group B (Ultrasound) to see comparison in efficiency of ultrasound guided against fluoroscopic guided genicular nerves block for decrease in pain intensity and functional improvement.

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Key information

Conditions

Chronic Knee Osteoarthritis

Age range

50 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Both gender patients of age more than 50 years.
  • Radiographic diagnosis of knee OA with KL level 3 and 4.
  • Chronic knee pain for more than 6 months
  • Patients with more than 50% reduction in pain intensity after diagnostic genicular nerve block

Exclusion criteria

  • Lack of consent
  • surgery of knee
  • Patient with BMI more than 40kg/m2
  • Intra-articular steroid injection or hyaluronic acid in last 3 months
  • Localized infection at procedure site or knee.
  • Patient unable to communicate properly (Severe psychiatric illness, severe dementia and cognitive impairment).
  • Patients have moderate to severe low back pain (NRS ≥5)

Treatment and study plan

Ultrasound guided

Procedure

Genicular nerves radiofrequency ablation will be done with the help of ultrasound guidance.

Fluoroscope Guided

Procedure

Control group in which genicular nerves radiofrequency ablation will be done with the help of fluoroscopic guidance.

Primary outcomes

  1. Effectiveness of Block

    Time frame: Post procedure 2 weeks, then follow up after 2, 4 and 6 months.

    Block will be considered effective if decrease in pain score from baseline is >50% at six months. And this will measure by using the 11-point Numeric Rating Scale (NRS) where 0 = no pain and 10 = worst imaginable pain.

Secondary outcomes

  1. Functional Improvement after block

    Time frame: 6 months

    Functional improvement after genicular nerve block is describe as > 20 % decrease in KOOS PS score from baseline at six months. Functional condition will be assessed using the Knee injury and osteoarthritis outcomes score-Physical function short form (KOOS-PS) tool. Minimum score is 0 and maximum is 20 which will then be converted into ratio from 0 to 100%, 0 means no functional impairment and 100 means maximum functional impairment.

Study contacts

Contact information is provided by the study sponsor or research team.

Ali Sarfraz Siddiqui, MBBS-FCPS

CONTACT

[email protected]

+92 021-38104397 ext. 4397

Sponsors and collaborators

Lead sponsor

Aga Khan University

Other

Registry information

Official study title

Efficacy of Ultrasound vs Fluoroscopy Guided Genicular Nerve Radiofrequency Ablation for Chronic Knee Osteoarthritis: A Randomized Controlled Trial

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Mar 17, 2026
Registry last updated
Mar 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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