IgG-4 Levels in Systemic Sclerosis

This is an observational - non interventional study. The investigators will compare IgG4 levels of 80 healthy donors (from Israel blood bank - MDA) and 80 Systemic Sclerosis patients from Meir Medical Center.

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Key information

Conditions

Systemic Sclerosis Connective Tissue Diseases Scleroderma, Systemic Skin Diseases Skin and Connective Tissue Diseases

Age range

18 year–85 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Meir Medical Center

Kfar Saba, Israel

About this study

IgG4 levels will be obtained from medical records of 80 SSc patients between the years 2000-2019. These will be compared to IgG4 levels from sera of 80 healthy donors (from Israel blood-bank - MDA). Correlations between IgG4 levels and the following will be made: age, sex, disease type (limited or diffused SSc), disease duration, medications.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

SSc patients

Exclusion criteria

other chronic co-morbidities

Treatment and study plan

IgG4 measurement (non-interventional, just obtaining data from medical records)

Diagnostic Test

IgG4 measurement in mg/dL

Primary outcomes

IgG4 measurement

Time frame: 4 months

quantifying IgG4 in each group and in SSc subgroups based on disease type, organs involved, medications.

Sponsors and collaborators

Lead sponsor

Meir Medical Center

Other

Registry information

Official study title

Comparing IgG-4 Levels in Systemic Sclerosis Patients vs. Healthy Controls

Acronym: SSc-IgG4

Important dates

Study start: 2019
Primary completion: 2024
Study completion: 2024
First posted: Jan 7, 2020
Registry last updated: May 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed