Skip to main content
OpenTrials
Completed

NCT Number: NCT01878058

Identifying Prostate Brachytherapy Seeds Using MRI

This study will look at the feasibility of using a type of Magnetic Resonance Imaging called Susceptibility Weighted Imaging (SWI) to detect your implanted radioactive seeds. Researchers hope that using SWI will eliminate the need to use CT imaging to detect your implanted radioactive seeds.

This study will also see if the MRI seed detection is as effective as current standard practice of seed detection (routine MRI and CT imaging). This technique would be beneficial for brachytherapy without the need to fuse the MRI and CT images, as is done currently.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Prostate Cancer Patients Who Have Brachytherapy Seed Implant Genital Diseases Genital Diseases, Male Genital Neoplasms, Male Male Urogenital Diseases Neoplasms Neoplasms by Site Prostatic Diseases Prostatic Neoplasms Urogenital Diseases Urogenital Neoplasms

Age range

18 year and older

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University Health Network, The Princess Margaret

Toronto, Ontario, M5G 2M9, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • At least 18 years old
  • Histologic diagnosis of adenocarcinoma of the prostate
  • No contraindications for Pelvic body MRI
  • Patients undergoing LDR brachytherapy at PMH and scheduled for post implant analysis with CT-MR (standard at PMH)
  • Ability to provide written informed consent to participate in the study

Exclusion criteria

  • Contraindication for Pelvic body MRI
  • Patient not willing/consenting for this study

Treatment and study plan

MRI scan

Other

Patient will receive an additional MRI scan in addition to their standard of care imaging

Primary outcomes

  1. Determine if using the MR scan -(SWI) used to detect the implanted radioactive seeds will reduce registration errors

    Time frame: 6 months

  2. Determine if using the MR scan -(SWI) used to detect the implanted radioactive seeds will reduce planning time for the post-implant plan

    Time frame: 6 months

  3. Determine if using the MR scan -(SWI) used to detect the implanted radioactive seeds will eliminate the CT scan of the patient.

    Time frame: 6 months

Secondary outcomes

  1. Compare the differences in MR seed identification using the MR pulse sequence vs. CT images.

    Time frame: 6 months

    Our goal is to perfectly match these two modalities with acceptance test of 97%. This technique would be beneficial for LDR (Low Dose Rate) Brachytherapy without need to fuse the CT and MR images and eliminate any image registration uncertainly.

Other outcomes

  1. Compare the prostate dosimetry (V100 and D90) in prostate low dose rate therapy using MR alone with CT/MR fusion.

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

University Health Network, Toronto

Other

Collaborators

  • Princess Margaret Hospital, Canada

Registry information

Important dates

Study start
2012
Primary completion
2016
Study completion
2016
First posted
Jun 14, 2013
Registry last updated
Nov 1, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.