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NCT Number: NCT06843512

Identifying Changes in Food Behaviors Associated With Beginning GLP-1 Medication

In recent years, GLP-1 medications have become a widely employed approach by physicians to address weight concerns in patients and lead to weight loss. Little is known, however, about how these medications may alter an individual's attitude towards food, food reactivity, or the specific types and amounts of foods an individual will choose. The purpose of this study is to observe the changes an individual experiences in their relationship and reaction to food and in their food selection prior to or within the first two weeks of taking GLP-1 medication to after three months on the medication. The researchers of this study believe that an understanding of such changes can inform questions seeking to ensure maintenance of appropriate nutrient balance within individuals on weight loss medications.

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Key information

Conditions

Weight Loss Behavior Body Weight Body Weight Changes Feeding Behavior Food Preferences Food Selection Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Health, Ingestive Behavior, and Technology Laboratory of Pennsylvania State University

State College, Pennsylvania, 16802, United States

Location status: Recruiting

Location contact

Christina M Blackmon

CONTACT

[email protected]

425-499-8049

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults (18+) with overweight or obesity (BMI >25 kg/m2)
  • Not currently taking an incretin-based medication at baseline
  • Recently (within two weeks) prescribed a GLP-1, can be included if they have a obesity-related co-occurring condition (diabetes, hypertension, cardiovascular disease, dyslipidemia)
  • Have had no prior diagnosis of cognitive or physical disability, dyslexia, or epilepsy.
  • Fluent in English

Exclusion criteria

  • Adults (18+) without overweight or obesity
  • <18 years of age at time of testing
  • Adults not taking a GLP-1 Medication
  • Adults taking a compound GLP-1
  • Adults on GLP-1 medication for longer than 2 weeks at baseline
  • Have had a prior diagnosis of cognitive or physical disability, dyslexia, or epilepsy.
  • Not fluent in English

Treatment and study plan

GLP-1 Medication Initiation

Other

One visit before starting GLP-1 medication and one visit 3 months after. No other changes administered between visits.

Primary outcomes

  1. Change from Baseline in Total Weight of Food Selected in the VR Buffet at 3 Months

    Time frame: Baseline and 3 months

  2. Change from Baseline in Total Calories of Food Selected in the VR Buffet at 3 Months

    Time frame: Baseline and 3 months

  3. Change from Baseline in Energy Density of Food Selected in the VR Buffet at 3 Months

    Time frame: Baseline and 3 months

  4. Change from Baseline in Variety of Food Selected in the VR Buffet at 3 Months

    Time frame: Baseline and 3 months

Secondary outcomes

  1. Change in Baseline Weight Watchers Food Noise Score at 3 Months

    Time frame: Baseline and 3 months

    Based on participant's answers to the WW Food Noise questionnaire; Scale of 1-5, 1 being strongly disagree and 5 being strongly agree; Higher scores mean more food noise

  2. Change in Baseline 9-question External Food Cue Responsiveness Questionnaire Score at 3 Months

    Time frame: Baseline and 3 months

    Answers are on a 1-4 scale with 1 being "Rarely" and 4 being "A lot"; higher scores suggest more external food cue reactivity

  3. Change in Baseline Adult Eating Behavior Score at 3 Months

    Time frame: Baseline and 3 months

    Answers on a 1-5 scale with 1 being "Strongly disagree" and 5 being "Strongly agree"; 8 subscales, high scores indicate greater expression of subscale measure

  4. Change in Baseline Three-Factor Eating Questionnaire Score at 3 Months

    Time frame: Baseline and 3 months

    Rated on a scale of 1-4 with 1 being "Definitely false" and 4 being "Definitely true"; 3 subscales, higher scales on each means greater expression of that behavior

  5. Change in Baseline General Food Craving-Trait Scale Score at 3 Months

    Time frame: Baseline and 3 months

    Rated on a 0-5 scale with 0 being "Never/not applicable" and 5 being "Always"; higher scores mean more food dependent

  6. Change in Baseline Buffet Food Liking Scores at 3 Months

    Time frame: Baseline and 3 months

    Rated on a 0-100 scale with 0 being "Dislike extremely" and 100 being "Like extremely"; high scores mean greater liking of the food

Other outcomes

  1. Change in Baseline BMI at 3 Months

    Time frame: Baseline and 3 months

    Calculated from height and weight collected at the end of both sessions

Study contacts

Contact information is provided by the study sponsor or research team.

Christina M Blackmon

CONTACT

[email protected]

425-499-8049

Sponsors and collaborators

Lead sponsor

Penn State University

Other

Registry information

Official study title

Exploring the Influence of GLP-1 Medication on Food Attitudes and Selection in a Virtual Reality Buffet

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Feb 25, 2025
Registry last updated
Sep 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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